Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection
Mesoporous silica materials (MSM) have a great surface area and a high pore volume, meaning that they consequently have a large loading capacity, and have been demonstrated to be unique candidates for the treatment of different pathologies, including bacterial infection. In this text, we review the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/10/4/279 |
| _version_ | 1811187400616968192 |
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| author | Marina Martínez-Carmona Yurii K. Gun’ko María Vallet-Regí |
| author_facet | Marina Martínez-Carmona Yurii K. Gun’ko María Vallet-Regí |
| author_sort | Marina Martínez-Carmona |
| collection | DOAJ |
| description | Mesoporous silica materials (MSM) have a great surface area and a high pore volume, meaning that they consequently have a large loading capacity, and have been demonstrated to be unique candidates for the treatment of different pathologies, including bacterial infection. In this text, we review the multiple ways of action in which MSM can be used to fight bacterial infection, including early detection, drug release, targeting bacteria or biofilm, antifouling surfaces, and adjuvant capacity. This review focus mainly on those that act as a drug delivery system, and therefore that have an essential characteristic, which is their great loading capacity. Since MSM have advantages in all stages of combatting bacterial infection; its prevention, detection and finally in its treatment, we can venture to talk about them as the “nightmare of bacteria„. |
| first_indexed | 2024-04-11T14:02:50Z |
| format | Article |
| id | doaj.art-950e1f1941434675ba9c39a44de75183 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T14:02:50Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-950e1f1941434675ba9c39a44de751832022-12-22T04:20:04ZengMDPI AGPharmaceutics1999-49232018-12-0110427910.3390/pharmaceutics10040279pharmaceutics10040279Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial InfectionMarina Martínez-Carmona0Yurii K. Gun’ko1María Vallet-Regí2School of Chemistry and CRANN, Trinity College, The University of Dublin, Dublin 2, IrelandSchool of Chemistry and CRANN, Trinity College, The University of Dublin, Dublin 2, IrelandDepartment Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, 28040 Madrid, SpainMesoporous silica materials (MSM) have a great surface area and a high pore volume, meaning that they consequently have a large loading capacity, and have been demonstrated to be unique candidates for the treatment of different pathologies, including bacterial infection. In this text, we review the multiple ways of action in which MSM can be used to fight bacterial infection, including early detection, drug release, targeting bacteria or biofilm, antifouling surfaces, and adjuvant capacity. This review focus mainly on those that act as a drug delivery system, and therefore that have an essential characteristic, which is their great loading capacity. Since MSM have advantages in all stages of combatting bacterial infection; its prevention, detection and finally in its treatment, we can venture to talk about them as the “nightmare of bacteria„.https://www.mdpi.com/1999-4923/10/4/279mesoporous silicadrug deliverybacterial infectionbacterial biofilmbiofilmantibiotic resistancetargeting bacteriatargeting biofilmmultifunctional nanoparticles |
| spellingShingle | Marina Martínez-Carmona Yurii K. Gun’ko María Vallet-Regí Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection Pharmaceutics mesoporous silica drug delivery bacterial infection bacterial biofilm biofilm antibiotic resistance targeting bacteria targeting biofilm multifunctional nanoparticles |
| title | Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection |
| title_full | Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection |
| title_fullStr | Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection |
| title_full_unstemmed | Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection |
| title_short | Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection |
| title_sort | mesoporous silica materials as drug delivery the nightmare of bacterial infection |
| topic | mesoporous silica drug delivery bacterial infection bacterial biofilm biofilm antibiotic resistance targeting bacteria targeting biofilm multifunctional nanoparticles |
| url | https://www.mdpi.com/1999-4923/10/4/279 |
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