SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4
Abstract Background Epithelial-to-mesenchymal transition (EMT) contributes to the invasion and metastasis of epithelial tumors. Sirtuin 6 (SIRT6), an NAD-dependent deacetylase, is known to promote metastasis of non-small cell lung cancer (NSCLC). Methods In this work, we determined the role of SIRT6...
Main Authors: | Ziming Li, Jia Huang, Shengping Shen, Zhenping Ding, Qingquan Luo, Zhiwei Chen, Shun Lu |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-12-01
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Series: | Journal of Experimental & Clinical Cancer Research |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13046-018-0984-z |
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