Mechanism and Prevention of Spiral Ganglion Neuron Degeneration in the Cochlea
Sensorineural hearing loss (SNHL) is one of the most prevalent sensory deficits in humans, and approximately 360 million people worldwide are affected. The current treatment option for severe to profound hearing loss is cochlear implantation (CI), but its treatment efficacy is related to the surviva...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2021.814891/full |
| _version_ | 1798034195692388352 |
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| author | Li Zhang Sen Chen Yu Sun Yu Sun |
| author_facet | Li Zhang Sen Chen Yu Sun Yu Sun |
| author_sort | Li Zhang |
| collection | DOAJ |
| description | Sensorineural hearing loss (SNHL) is one of the most prevalent sensory deficits in humans, and approximately 360 million people worldwide are affected. The current treatment option for severe to profound hearing loss is cochlear implantation (CI), but its treatment efficacy is related to the survival of spiral ganglion neurons (SGNs). SGNs are the primary sensory neurons, transmitting complex acoustic information from hair cells to second-order sensory neurons in the cochlear nucleus. In mammals, SGNs have very limited regeneration ability, and SGN loss causes irreversible hearing loss. In most cases of SNHL, SGN damage is the dominant pathogenesis, and it could be caused by noise exposure, ototoxic drugs, hereditary defects, presbycusis, etc. Tremendous efforts have been made to identify novel treatments to prevent or reverse the damage to SGNs, including gene therapy and stem cell therapy. This review summarizes the major causes and the corresponding mechanisms of SGN loss and the current protection strategies, especially gene therapy and stem cell therapy, to promote the development of new therapeutic methods. |
| first_indexed | 2024-04-11T20:40:49Z |
| format | Article |
| id | doaj.art-950ed78c05fd41058c9f040e54bee32f |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-11T20:40:49Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-950ed78c05fd41058c9f040e54bee32f2022-12-22T04:04:13ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-01-011510.3389/fncel.2021.814891814891Mechanism and Prevention of Spiral Ganglion Neuron Degeneration in the CochleaLi Zhang0Sen Chen1Yu Sun2Yu Sun3Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Otorhinolaryngology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSensorineural hearing loss (SNHL) is one of the most prevalent sensory deficits in humans, and approximately 360 million people worldwide are affected. The current treatment option for severe to profound hearing loss is cochlear implantation (CI), but its treatment efficacy is related to the survival of spiral ganglion neurons (SGNs). SGNs are the primary sensory neurons, transmitting complex acoustic information from hair cells to second-order sensory neurons in the cochlear nucleus. In mammals, SGNs have very limited regeneration ability, and SGN loss causes irreversible hearing loss. In most cases of SNHL, SGN damage is the dominant pathogenesis, and it could be caused by noise exposure, ototoxic drugs, hereditary defects, presbycusis, etc. Tremendous efforts have been made to identify novel treatments to prevent or reverse the damage to SGNs, including gene therapy and stem cell therapy. This review summarizes the major causes and the corresponding mechanisms of SGN loss and the current protection strategies, especially gene therapy and stem cell therapy, to promote the development of new therapeutic methods.https://www.frontiersin.org/articles/10.3389/fncel.2021.814891/fullspiral ganglion neuronsensorineural hearing lossgene therapystem cell therapycochlea |
| spellingShingle | Li Zhang Sen Chen Yu Sun Yu Sun Mechanism and Prevention of Spiral Ganglion Neuron Degeneration in the Cochlea Frontiers in Cellular Neuroscience spiral ganglion neuron sensorineural hearing loss gene therapy stem cell therapy cochlea |
| title | Mechanism and Prevention of Spiral Ganglion Neuron Degeneration in the Cochlea |
| title_full | Mechanism and Prevention of Spiral Ganglion Neuron Degeneration in the Cochlea |
| title_fullStr | Mechanism and Prevention of Spiral Ganglion Neuron Degeneration in the Cochlea |
| title_full_unstemmed | Mechanism and Prevention of Spiral Ganglion Neuron Degeneration in the Cochlea |
| title_short | Mechanism and Prevention of Spiral Ganglion Neuron Degeneration in the Cochlea |
| title_sort | mechanism and prevention of spiral ganglion neuron degeneration in the cochlea |
| topic | spiral ganglion neuron sensorineural hearing loss gene therapy stem cell therapy cochlea |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2021.814891/full |
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