RhANP attenuates endotoxin-derived cognitive dysfunction through subdiaphragmatic vagus nerve-mediated gut microbiota–brain axis

RhANP attenuates endotoxin-derived cognitive dysfunction through subdiaphragmatic vagus nerve-mediated gut microbiota–brain axis

Abstract Background Atrial natriuretic peptide (ANP) secreted from atrial myocytes is shown to possess anti-inflammatory, anti-oxidant and immunomodulatory effects. The aim of this study is to assess the effect of ANP on bacterial lipopolysaccharide (LPS)-induced endotoxemia-derived neuroinflammatio...

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Bibliographic Details
Main Authors: Yuming Wu, Yujing Zhang, Bing Xie, Amro Abdelgawad, Xiaoyan Chen, Mengqi Han, You Shang, Shiying Yuan, Jiancheng Zhang
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Journal of Neuroinflammation
Subjects:
Cognition
Gut microbiota
LPS
Neuroinflammation
Subdiaphragmatic vagus nerve
Online Access:https://doi.org/10.1186/s12974-021-02356-z

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