A Combined mRNA- and miRNA-Sequencing Approach Reveals miRNAs as Potential Regulators of the Small Intestinal Transcriptome in Celiac Disease

A Combined mRNA- and miRNA-Sequencing Approach Reveals miRNAs as Potential Regulators of the Small Intestinal Transcriptome in Celiac Disease

Celiac disease (CeD) is triggered by gluten and results in inflammation and villous atrophy of the small intestine. We aimed to explore the role of miRNA-mediated deregulation of the transcriptome in CeD. Duodenal biopsies of CeD patients (<i>n</i> = 33) and control subjects (<i>n&...

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Bibliographic Details
Main Authors: Ineke Luise Tan, Donatella Barisani, Roberto Panceri, Rutger Modderman, Marijn Visschedijk, Rinse K. Weersma, Cisca Wijmenga, Iris Jonkers, Rodrigo Coutinho de Almeida, Sebo Withoff
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
miRNA‒target gene regulation
post-translational transcript regulation
autoimmunity
Online Access:https://www.mdpi.com/1422-0067/22/21/11382

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