Controlling nutritional status score during hospitalization as a predictor of clinical outcome in patients with aneurysmal subarachnoid hemorrhage
Abstract Aneurysmal subarachnoid hemorrhage (aSAH) is a serious condition with high mortality and a high permanent disability rate. In this study, we examined the association of clinical outcome with the Controlling Nutritional Status (CONUT) score during hospitalization in aSAH patients. A single-c...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-08-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-39938-1 |
| _version_ | 1797452926775459840 |
|---|---|
| author | Shinya Shimizu Tatsunori Hanai Yusuke Egashira Yukina Sato Kumiko Sekiya Shohei Nishida Masashi Ishihara Takuma Ishihara Ryuta Asada Ryo Kobayashi Akio Suzuki |
| author_facet | Shinya Shimizu Tatsunori Hanai Yusuke Egashira Yukina Sato Kumiko Sekiya Shohei Nishida Masashi Ishihara Takuma Ishihara Ryuta Asada Ryo Kobayashi Akio Suzuki |
| author_sort | Shinya Shimizu |
| collection | DOAJ |
| description | Abstract Aneurysmal subarachnoid hemorrhage (aSAH) is a serious condition with high mortality and a high permanent disability rate. In this study, we examined the association of clinical outcome with the Controlling Nutritional Status (CONUT) score during hospitalization in aSAH patients. A single-center, retrospective observational study was conducted at Gifu University Hospital. Patients transported to the emergency room for aSAH and diagnosed with World Federation of Neurosurgical Societies (WFNS) grade III and IV aSAH between April 2004 and March 2021 were enrolled. A logistic regression model was constructed to evaluate the association of the CONUT score with a modified Rankin scale (mRS) ≥ 3 and delayed cerebral ischemia (DCI). 127 patients diagnosed with WFNS grade III and IV aSAH were analyzed. CONUT score was significantly associated with mRS ≥ 3 during hospitalization. The score obtained by subtracting the CONUT score at admission from the maximum CONUT score was significantly associated with mRS ≥ 3 at discharge. Moreover, the score obtained by subtracting the CONUT score at admission from the maximum CONUT score during the first 14 days was significantly associated with DCI within 14 days from admission. These findings indicate that CONUT score during hospitalization may be a useful daily marker for predicting poor outcomes in aSAH patients. |
| first_indexed | 2024-03-09T15:15:45Z |
| format | Article |
| id | doaj.art-951a2e495c544d4080fafb2491f8afe4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:15:45Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-951a2e495c544d4080fafb2491f8afe42023-11-26T13:06:51ZengNature PortfolioScientific Reports2045-23222023-08-011311910.1038/s41598-023-39938-1Controlling nutritional status score during hospitalization as a predictor of clinical outcome in patients with aneurysmal subarachnoid hemorrhageShinya Shimizu0Tatsunori Hanai1Yusuke Egashira2Yukina Sato3Kumiko Sekiya4Shohei Nishida5Masashi Ishihara6Takuma Ishihara7Ryuta Asada8Ryo Kobayashi9Akio Suzuki10Department of Pharmacy, Gifu University HospitalFirst Department of Internal Medicine, Gifu University HospitalDepartment of Neurosurgery, Gifu University Graduate School of MedicineDepartment of Pharmacy, Gifu University HospitalDepartment of Pharmacy, Gifu University HospitalDepartment of Pharmacy, Gifu University HospitalInnovative and Clinical Research Promotion Center, Gifu University HospitalInnovative and Clinical Research Promotion Center, Gifu University HospitalInnovative and Clinical Research Promotion Center, Gifu University HospitalDepartment of Pharmacy, Gifu University HospitalDepartment of Pharmacy, Gifu University HospitalAbstract Aneurysmal subarachnoid hemorrhage (aSAH) is a serious condition with high mortality and a high permanent disability rate. In this study, we examined the association of clinical outcome with the Controlling Nutritional Status (CONUT) score during hospitalization in aSAH patients. A single-center, retrospective observational study was conducted at Gifu University Hospital. Patients transported to the emergency room for aSAH and diagnosed with World Federation of Neurosurgical Societies (WFNS) grade III and IV aSAH between April 2004 and March 2021 were enrolled. A logistic regression model was constructed to evaluate the association of the CONUT score with a modified Rankin scale (mRS) ≥ 3 and delayed cerebral ischemia (DCI). 127 patients diagnosed with WFNS grade III and IV aSAH were analyzed. CONUT score was significantly associated with mRS ≥ 3 during hospitalization. The score obtained by subtracting the CONUT score at admission from the maximum CONUT score was significantly associated with mRS ≥ 3 at discharge. Moreover, the score obtained by subtracting the CONUT score at admission from the maximum CONUT score during the first 14 days was significantly associated with DCI within 14 days from admission. These findings indicate that CONUT score during hospitalization may be a useful daily marker for predicting poor outcomes in aSAH patients.https://doi.org/10.1038/s41598-023-39938-1 |
| spellingShingle | Shinya Shimizu Tatsunori Hanai Yusuke Egashira Yukina Sato Kumiko Sekiya Shohei Nishida Masashi Ishihara Takuma Ishihara Ryuta Asada Ryo Kobayashi Akio Suzuki Controlling nutritional status score during hospitalization as a predictor of clinical outcome in patients with aneurysmal subarachnoid hemorrhage Scientific Reports |
| title | Controlling nutritional status score during hospitalization as a predictor of clinical outcome in patients with aneurysmal subarachnoid hemorrhage |
| title_full | Controlling nutritional status score during hospitalization as a predictor of clinical outcome in patients with aneurysmal subarachnoid hemorrhage |
| title_fullStr | Controlling nutritional status score during hospitalization as a predictor of clinical outcome in patients with aneurysmal subarachnoid hemorrhage |
| title_full_unstemmed | Controlling nutritional status score during hospitalization as a predictor of clinical outcome in patients with aneurysmal subarachnoid hemorrhage |
| title_short | Controlling nutritional status score during hospitalization as a predictor of clinical outcome in patients with aneurysmal subarachnoid hemorrhage |
| title_sort | controlling nutritional status score during hospitalization as a predictor of clinical outcome in patients with aneurysmal subarachnoid hemorrhage |
| url | https://doi.org/10.1038/s41598-023-39938-1 |
| work_keys_str_mv | AT shinyashimizu controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage AT tatsunorihanai controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage AT yusukeegashira controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage AT yukinasato controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage AT kumikosekiya controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage AT shoheinishida controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage AT masashiishihara controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage AT takumaishihara controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage AT ryutaasada controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage AT ryokobayashi controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage AT akiosuzuki controllingnutritionalstatusscoreduringhospitalizationasapredictorofclinicaloutcomeinpatientswithaneurysmalsubarachnoidhemorrhage |