The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis.
BACKGROUND: The association of diabetes mellitus (DM) with nonarteritic anterior ischemic optic neuropathy (NAION) has been inconclusive. PURPOSE: To determine whether DM is associated with an increased risk of NAION. METHODS: A comprehensive literature search was performed for published studies rep...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3786911?pdf=render |
| _version_ | 1818040470670934016 |
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| author | Ting Chen Delu Song Guangliang Shan Ke Wang Yiwei Wang Jin Ma Yong Zhong |
| author_facet | Ting Chen Delu Song Guangliang Shan Ke Wang Yiwei Wang Jin Ma Yong Zhong |
| author_sort | Ting Chen |
| collection | DOAJ |
| description | BACKGROUND: The association of diabetes mellitus (DM) with nonarteritic anterior ischemic optic neuropathy (NAION) has been inconclusive. PURPOSE: To determine whether DM is associated with an increased risk of NAION. METHODS: A comprehensive literature search was performed for published studies reporting both DM and NAION based on PubMed and EMBASE. After reviewing characteristics of all the included studies systematically, meta-analytical method was employed to calculate the pooled odds ratio (OR) and associated 95% confidence interval (CI) from random-effects models. Heterogeneity was assessed by Q-statistic test. Funnel Plot, Begg's and Egger's linear regression test were applied to evaluate publication bias. A sensitivity analysis and meta-regression analysis were also performed to assess the robustness of results. RESULTS: 2,096 participants from 12 case-control studies were pooled for a meta-analysis. The result of meta-analysis of these studies indicated that DM is associated with increased risk of NAION (pooled OR = 1.64, 95% CI = 1.17-2.30; P = 0.004). Sensitivity analysis indicated our findings are robust, and meta-regression analysis revealed no significant effect in terms of geographical area, gender, age of patients with NAION, the year of the publication, source of the controls, and sample size (all p>0.05). Evidence of publication bias was not observed in our study. CONCLUSION: Meta-analysis suggests that DM might be associated with increased risk of NAION. |
| first_indexed | 2024-12-10T08:15:03Z |
| format | Article |
| id | doaj.art-951ad5e418a44d7fb04dd7ee55913f3e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T08:15:03Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-951ad5e418a44d7fb04dd7ee55913f3e2022-12-22T01:56:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7665310.1371/journal.pone.0076653The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis.Ting ChenDelu SongGuangliang ShanKe WangYiwei WangJin MaYong ZhongBACKGROUND: The association of diabetes mellitus (DM) with nonarteritic anterior ischemic optic neuropathy (NAION) has been inconclusive. PURPOSE: To determine whether DM is associated with an increased risk of NAION. METHODS: A comprehensive literature search was performed for published studies reporting both DM and NAION based on PubMed and EMBASE. After reviewing characteristics of all the included studies systematically, meta-analytical method was employed to calculate the pooled odds ratio (OR) and associated 95% confidence interval (CI) from random-effects models. Heterogeneity was assessed by Q-statistic test. Funnel Plot, Begg's and Egger's linear regression test were applied to evaluate publication bias. A sensitivity analysis and meta-regression analysis were also performed to assess the robustness of results. RESULTS: 2,096 participants from 12 case-control studies were pooled for a meta-analysis. The result of meta-analysis of these studies indicated that DM is associated with increased risk of NAION (pooled OR = 1.64, 95% CI = 1.17-2.30; P = 0.004). Sensitivity analysis indicated our findings are robust, and meta-regression analysis revealed no significant effect in terms of geographical area, gender, age of patients with NAION, the year of the publication, source of the controls, and sample size (all p>0.05). Evidence of publication bias was not observed in our study. CONCLUSION: Meta-analysis suggests that DM might be associated with increased risk of NAION.http://europepmc.org/articles/PMC3786911?pdf=render |
| spellingShingle | Ting Chen Delu Song Guangliang Shan Ke Wang Yiwei Wang Jin Ma Yong Zhong The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. PLoS ONE |
| title | The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. |
| title_full | The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. |
| title_fullStr | The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. |
| title_full_unstemmed | The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. |
| title_short | The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. |
| title_sort | association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy a systematic review and meta analysis |
| url | http://europepmc.org/articles/PMC3786911?pdf=render |
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