Commentary: GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response

Commentary: GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response

Bibliographic Details
Main Authors:	Andre De Souza, Fabio A. Tavora, Devalingam Mahalingam, Pamela N. Munster, Howard P. Safran, Wafik S. El-Deiry, Benedito A. Carneiro
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-10-01
Series:	Frontiers in Immunology
Subjects:	glycogen synthase kinase-3 (GSK3) glycogen synthase kinase-3 (GSK-3) inhibitor COVID COVID-19 9-ING-41 GSK-3b inhibitor
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2020.595289/full

Similar Items

Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma
by: Andrew Hsu, et al.
Published: (2022-12-01)

GSK-3 protein and the heart: friend or foe?
by: B. Huisamen, et al.
Published: (2017-04-01)

TEST-SYSTEM FOR ESTIMATION OF ACTIVITY OF GSK-3 INHIBITORS AS ANTIHYPOXANTS AND DIFFERENTIATION OF ENDOTHELIAL PROGENITORS IN VITRO
by: Youri Burda, et al.
Published: (2016-03-01)

Increase in Subcellular GSK-3 Clusters in Insulin- and Adrenaline-treated Differentiated Rat Skeletal Muscle Fibres
by: Katja Fink, et al.
Published: (2020-04-01)

Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it’s role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review
by: A. Ullah, et al.
Published: (2021-09-01)

Regulatory network of GSK3-like kinases and their role in plant stress response
by: Yun Song, et al.
Published: (2023-03-01)

Glycogen synthase kinase 3 (GSK-3) and its inhibitors : drug discovery and development /
by: Martinez, Ana, 1961-, et al.
Published: (2006)

Using Topological Indices to Predict Anti-Alzheimer and Anti-Parasitic GSK-3 Inhibitors by Multi-Target QSAR in Silico Screening
by: Generosa Gómez, et al.
Published: (2010-08-01)

Macrophage Function and the Role of GSK3
by: Sarvatit Patel, et al.
Published: (2021-02-01)

Somatostatin-SSTR3-GSK3 modulates human T-cell responses by inhibiting OXPHOS
by: Bo Zhang, et al.
Published: (2024-02-01)

Brassinazole Resistant 1 Activity Is Organ-Specific and Genotype-Dependent in Barley Seedlings
by: Jolanta Groszyk, et al.
Published: (2021-12-01)

Glycogen synthase kinase-3: A promising therapeutic target for Fragile X Syndrome
by: Marjelo M. Mines, et al.
Published: (2011-11-01)

Effects of GSK-3 inhibition on LPS-induced neuroinflammation and IL-10 production in microglia
by: Md Zain, Zuhaida
Published: (2016)

Integrating Machine Learning-Based Virtual Screening With Multiple Protein Structures and Bio-Assay Evaluation for Discovery of Novel GSK3β Inhibitors
by: Jingyu Zhu, et al.
Published: (2020-09-01)

4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A
by: Roland Houben, et al.
Published: (2023-04-01)

Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3α Promotes Atherosclerotic Regression in <i>Ldlr</i><sup>−/−</sup> Mice
by: Sarvatit Patel, et al.
Published: (2022-08-01)

Elraglusib (formerly 9-ING-41) possesses potent anti-lymphoma properties which cannot be attributed to GSK3 inhibition
by: Josh T. Coats, et al.
Published: (2023-06-01)

Test-system for the assessment of GSK-3 inhibitors activity as antihypoxants and endothelial differentiation stimulators <i>in vitro</i>
by: Yu. E. Burda, et al.
Published: (2018-02-01)

Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro
by: Selvi Kunnimalaiyaan, et al.
Published: (2018-05-01)

Role of GSK-3β Inhibitors: New Promises and Opportunities for Alzheimer’s Disease
by: Suggala Ramya Shri, et al.
Published: (2023-11-01)

GSK3-beta as a candidate therapeutic target in soft tissue sarcomas
by: S. Verbeke, et al.
Published: (2021-12-01)

Akt signaling pathway: a potential therapy for Alzheimer’s disease through glycogen synthase kinase 3 beta inhibition
by: Joshua Limantoro, et al.
Published: (2023-11-01)

Amniotic fluid exerts a neurotrophic influence on fetal neurodevelopment via the ERK/GSK-3 pathway
by: Yongwoo Jang, et al.
Published: (2015-01-01)

GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer
by: Kelsey E. Huntington, et al.
Published: (2023-06-01)

When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex
by: Chenchen Li, et al.
Published: (2023-09-01)

Intermittent Fasting Modulates the Glycogen Level in Zebrafish (Danio rerio) and their Next Generation
by: ShanmugaSundaram Tamilarasan, et al.
Published: (2022-12-01)

Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend <i>C. elegans</i> Life- and Healthspan
by: Samuel Kakraba, et al.
Published: (2023-10-01)

A pivotal role of GSK-3 in synaptic plasticity
by: Clarrisa A Bradley, et al.
Published: (2012-02-01)

Effect of Xenon on the Phosphorylation of Glycogen Synthase Kinase 3β and Antioxidant Enzymes in Rat Brain
by: A. N. Kuzovlev, et al.
Published: (2021-01-01)

Molecular docking study of xylogranatins binding to glycogen synthase kinase-3β
by: Christian Bailly, et al.
Published: (2022-03-01)

GSK-3β in Pancreatic Cancer: Spotlight on 9-ING-41, Its Therapeutic Potential and Immune Modulatory Properties
by: Robin Park, et al.
Published: (2021-07-01)

GSK3α: An Important Paralog in Neurodegenerative Disorders and Cancer
by: Octavio Silva-García, et al.
Published: (2020-12-01)

Fluoride as a Potential Repressor of Glycogen Metabolism in Skeletal Muscle Cell Line CCL136
by: Izabela Gutowska, et al.
Published: (2023-08-01)

GSK3β Inhibition Ameliorates Atherosclerotic Calcification
by: Xinjiang Cai, et al.
Published: (2023-07-01)

A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells
by: Nigel Kurgan, et al.
Published: (2019-10-01)

Inhibition of AKT Signaling Alters βIV Spectrin Distribution at the AIS and Increases Neuronal Excitability
by: Jessica Di Re, et al.
Published: (2021-06-01)

Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.
by: Cheenpracha, Sarot, et al.
Published: (2009)

Involvement of Glycogen Synthase Kinase 3β (GSK3β) in Formation of Phosphorylated Tau and Death of Retinal Ganglion Cells of Rats Caused by Optic Nerve Crush
by: Yurie Fukiyama, et al.
Published: (2023-08-01)

Pharmacological Melanocortin 5 Receptor Activation Attenuates Glomerular Injury and Proteinuria in Rats With Puromycin Aminonucleoside Nephrosis
by: Bohan Chen, et al.
Published: (2022-06-01)

GSK-3β Inhibition Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via Down-Regulation of IL-6
by: Bailong Li, et al.
Published: (2013-12-01)