Insights into pyrrolysine function from structures of a trimethylamine methyltransferase and its corrinoid protein complex

Structures of Methanosarcina barkeri trimethylamine methyltransferase (MttB) with its substrates reveal the role of pyrrolysine in methyl group transfer from trimethylamine to the corrinoid cofactor in MttC.

Bibliographic Details
Main Authors: Jiaxin Li, Patrick T. Kang, Ruisheng Jiang, Jodie Y. Lee, Jitesh A. Soares, Joseph A. Krzycki, Michael K. Chan
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04397-3
Description
Summary:Structures of Methanosarcina barkeri trimethylamine methyltransferase (MttB) with its substrates reveal the role of pyrrolysine in methyl group transfer from trimethylamine to the corrinoid cofactor in MttC.
ISSN:2399-3642