Comparative characteristics of original and non-original sevoflurane in urological operations in children: a prospective study results
The study objective is to evaluate the effectiveness and safety of the original and non-original sevoflurane during urological operations in children.Materials and methods. Patients of urological profile 3—6 years old without comorbid pathology underwent surgery lasting no more than 40 min under inh...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2020-11-01
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| Series: | Андрология и генитальная хирургия |
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| Online Access: | https://agx.abvpress.ru/jour/article/view/435 |
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| author | D. V. Prometnoy A. D. Mayorov М. V. Bykov V. O. Fedyushkina P. Е. Anchutin А. D. Pamfiynik S. A. Razumov |
| author_facet | D. V. Prometnoy A. D. Mayorov М. V. Bykov V. O. Fedyushkina P. Е. Anchutin А. D. Pamfiynik S. A. Razumov |
| author_sort | D. V. Prometnoy |
| collection | DOAJ |
| description | The study objective is to evaluate the effectiveness and safety of the original and non-original sevoflurane during urological operations in children.Materials and methods. Patients of urological profile 3—6 years old without comorbid pathology underwent surgery lasting no more than 40 min under inhalation anesthesia: in group 1 — original sevoflurane (n = 11), group 2 — non-original sevoflurane (n = 11). The depth of anesthesia was evaluated using bispectral index monitoring.Results. In the group of non-original sevoflurane, the excitation syndrome before the beginning of anesthesia and in its introductory period was noted in 54.5 and 72.7 % respectively, the reaction to the introduction of a laryngeal mask — in 36.4 % of patients in the absence of these reactions in the group of the original drug. There was a higher depth of anesthesia in non-original drug with the achievement of statistically significant differences in the indicator at 15 and 20 min: 44 (42; 46) vs 50 (49; 54; p = 0.0001) and 42 (40; 46) vs 50 (47; 56; p = 0.003) respectively, as well unstable level of depth of anesthesia of the group of non-original sevoflurane compared to the original during the period of maintaining anesthesia.Conclusion. Despite the same formula of the original and non-original sevoflurane, the non-original drug was characterized by a greater frequency of excitation syndrome and reaction to the introduction of a laryngeal mask and unstable depth of anesthesia. |
| first_indexed | 2024-04-10T03:52:53Z |
| format | Article |
| id | doaj.art-952120227e3040e4944e6a5502703208 |
| institution | Directory Open Access Journal |
| issn | 2070-9781 |
| language | Russian |
| last_indexed | 2024-04-10T03:52:53Z |
| publishDate | 2020-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Андрология и генитальная хирургия |
| spelling | doaj.art-952120227e3040e4944e6a55027032082023-03-13T07:15:10ZrusABV-pressАндрология и генитальная хирургия2070-97812020-11-01213303710.17650/2070-9781-2020-21-3-30-37374Comparative characteristics of original and non-original sevoflurane in urological operations in children: a prospective study resultsD. V. Prometnoy0A. D. Mayorov1М. V. Bykov2V. O. Fedyushkina3P. Е. Anchutin4А. D. Pamfiynik5S. A. Razumov6Moscow Regional Center for Maternity and Childhood Protection; Saint Petersburg State Pediatric Medical University, Ministry of Health of RussiaMoscow Regional Center for Maternity and Childhood ProtectionMoscow Regional Center for Maternity and Childhood Protection; N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaMoscow Regional Center for Maternity and Childhood ProtectionV.A. Negovsky Scientific Research Institute of General Reanimatology, the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Ministry of Health of RussiaV.A. Negovsky Scientific Research Institute of General Reanimatology, the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Ministry of Health of RussiaAstana Medical UniversityThe study objective is to evaluate the effectiveness and safety of the original and non-original sevoflurane during urological operations in children.Materials and methods. Patients of urological profile 3—6 years old without comorbid pathology underwent surgery lasting no more than 40 min under inhalation anesthesia: in group 1 — original sevoflurane (n = 11), group 2 — non-original sevoflurane (n = 11). The depth of anesthesia was evaluated using bispectral index monitoring.Results. In the group of non-original sevoflurane, the excitation syndrome before the beginning of anesthesia and in its introductory period was noted in 54.5 and 72.7 % respectively, the reaction to the introduction of a laryngeal mask — in 36.4 % of patients in the absence of these reactions in the group of the original drug. There was a higher depth of anesthesia in non-original drug with the achievement of statistically significant differences in the indicator at 15 and 20 min: 44 (42; 46) vs 50 (49; 54; p = 0.0001) and 42 (40; 46) vs 50 (47; 56; p = 0.003) respectively, as well unstable level of depth of anesthesia of the group of non-original sevoflurane compared to the original during the period of maintaining anesthesia.Conclusion. Despite the same formula of the original and non-original sevoflurane, the non-original drug was characterized by a greater frequency of excitation syndrome and reaction to the introduction of a laryngeal mask and unstable depth of anesthesia.https://agx.abvpress.ru/jour/article/view/435sevofluraneoriginal drugnonoriginal druggeneric druganesthesiachildren |
| spellingShingle | D. V. Prometnoy A. D. Mayorov М. V. Bykov V. O. Fedyushkina P. Е. Anchutin А. D. Pamfiynik S. A. Razumov Comparative characteristics of original and non-original sevoflurane in urological operations in children: a prospective study results Андрология и генитальная хирургия sevoflurane original drug nonoriginal drug generic drug anesthesia children |
| title | Comparative characteristics of original and non-original sevoflurane in urological operations in children: a prospective study results |
| title_full | Comparative characteristics of original and non-original sevoflurane in urological operations in children: a prospective study results |
| title_fullStr | Comparative characteristics of original and non-original sevoflurane in urological operations in children: a prospective study results |
| title_full_unstemmed | Comparative characteristics of original and non-original sevoflurane in urological operations in children: a prospective study results |
| title_short | Comparative characteristics of original and non-original sevoflurane in urological operations in children: a prospective study results |
| title_sort | comparative characteristics of original and non original sevoflurane in urological operations in children a prospective study results |
| topic | sevoflurane original drug nonoriginal drug generic drug anesthesia children |
| url | https://agx.abvpress.ru/jour/article/view/435 |
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