Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley rats
The anti-inflammatory properties of Loasa speciosa and Loasa triphylla (Loasaceae), Urtica leptuphylla and Urera baccifera (Urticaceae), and Chaptalia nutans (Asteraceae) were studied using the carregeenan induced rat paw edema model. Aqueous extracts of each plant were made according to the ethnobo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidad de Costa Rica
1999-12-01
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| Series: | Revista de Biología Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0034-77441999000400009 |
| _version_ | 1827163254697230336 |
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| author | Beatriz Badilla Gerardo Mora Luis Jorge Poveda |
| author_facet | Beatriz Badilla Gerardo Mora Luis Jorge Poveda |
| author_sort | Beatriz Badilla |
| collection | DOAJ |
| description | The anti-inflammatory properties of Loasa speciosa and Loasa triphylla (Loasaceae), Urtica leptuphylla and Urera baccifera (Urticaceae), and Chaptalia nutans (Asteraceae) were studied using the carregeenan induced rat paw edema model. Aqueous extracts of each plant were made according to the ethnobotanical use. The hippocratic assay was made with female rats; the dose used was 500 mg/kg i.p. and the control group received 0.5 ml of n.s.s.. All the animals treated showed hipothermia, and those treated with the extracts of Chaptalia nutans, Urera baccifera and Urtica leptuphylla showed an increased colinergic activity. Acute toxicities of the aqueous extracts were studied in mice an the mean lethal doses ranged between 1.0226 and 1.2022 g/kg. The extracts of Urera baccifera, Chaptalia nutans, Loasa speciosa and Loasa triphylla (500 mg/kg i.p.) showed an anti-inflammatory activity comparable with that of indomethacin. The extracts of U. baccifera and C. nutans, which showed the greatest anti-inflammatory activity, did not show it when used orally (500 mg/kg p.o.). |
| first_indexed | 2024-03-12T10:28:54Z |
| format | Article |
| id | doaj.art-9523778d5f3d41c895f3b26e0300b72e |
| institution | Directory Open Access Journal |
| issn | 0034-7744 2215-2075 |
| language | English |
| last_indexed | 2025-03-21T00:57:47Z |
| publishDate | 1999-12-01 |
| publisher | Universidad de Costa Rica |
| record_format | Article |
| series | Revista de Biología Tropical |
| spelling | doaj.art-9523778d5f3d41c895f3b26e0300b72e2024-08-03T04:43:22ZengUniversidad de Costa RicaRevista de Biología Tropical0034-77442215-20751999-12-01474723727Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley ratsBeatriz BadillaGerardo MoraLuis Jorge PovedaThe anti-inflammatory properties of Loasa speciosa and Loasa triphylla (Loasaceae), Urtica leptuphylla and Urera baccifera (Urticaceae), and Chaptalia nutans (Asteraceae) were studied using the carregeenan induced rat paw edema model. Aqueous extracts of each plant were made according to the ethnobotanical use. The hippocratic assay was made with female rats; the dose used was 500 mg/kg i.p. and the control group received 0.5 ml of n.s.s.. All the animals treated showed hipothermia, and those treated with the extracts of Chaptalia nutans, Urera baccifera and Urtica leptuphylla showed an increased colinergic activity. Acute toxicities of the aqueous extracts were studied in mice an the mean lethal doses ranged between 1.0226 and 1.2022 g/kg. The extracts of Urera baccifera, Chaptalia nutans, Loasa speciosa and Loasa triphylla (500 mg/kg i.p.) showed an anti-inflammatory activity comparable with that of indomethacin. The extracts of U. baccifera and C. nutans, which showed the greatest anti-inflammatory activity, did not show it when used orally (500 mg/kg p.o.).http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0034-77441999000400009Medicinal plantsanti-inflammmatory agentedemaUrticaceaeAsteraceaeLoasaceae |
| spellingShingle | Beatriz Badilla Gerardo Mora Luis Jorge Poveda Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley rats Revista de Biología Tropical Medicinal plants anti-inflammmatory agent edema Urticaceae Asteraceae Loasaceae |
| title | Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley rats |
| title_full | Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley rats |
| title_fullStr | Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley rats |
| title_full_unstemmed | Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley rats |
| title_short | Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley rats |
| title_sort | anti inflammatory activity of aqueous extracts of five costa rican medicinal plants in sprague dawley rats |
| topic | Medicinal plants anti-inflammmatory agent edema Urticaceae Asteraceae Loasaceae |
| url | http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0034-77441999000400009 |
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