HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression

HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression

Summary: B cells generate functionally different classes of antibodies through class-switch recombination (CSR), which requires classical non-homologous end joining (C-NHEJ) to join the DNA breaks at the donor and acceptor switch (S) regions. We show that the RNA-binding protein HNRNPU promotes C-NH...

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Bibliographic Details
Main Authors: Ahmed M. Refaat, Mikiyo Nakata, Afzal Husain, Hidetaka Kosako, Tasuku Honjo, Nasim A. Begum
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723002954

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http://www.sciencedirect.com/science/article/pii/S2211124723002954

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