A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels

A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels

Resurgent currents (INaR) produced by voltage-gated sodium channels are required for many neurons to maintain high-frequency firing and contribute to neuronal hyperexcitability and disease pathophysiology. Here, we show, for the first time, that INaR can be reconstituted in a heterologous system by...

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Bibliographic Details
Main Authors: Yucheng Xiao, Jonathan W Theile, Agnes Zybura, Yanling Pan, Zhixin Lin, Theodore R Cummins
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
sodium channel
resurgent currents
FHF
Navβ4
dorsal root ganglion
Online Access:https://elifesciences.org/articles/77558

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