Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DC
Gnaphalium hypoleucum DC is used as a wild vegetable, named “Qing Ming Cai”, as well as a folk medicine in China. One new compound, Gnaphaliin C, and nineteen known compounds were isolated and indentified from G. hypoleucum, total flavonoids were analyzed by UHPLC-Q-TOF/MS. The α-glucosidase inhibit...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-11-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617305157 |
| _version_ | 1818950116271194112 |
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| author | Qun Sun Nai-Yu Xu Qi-Run Li Shi Yao Meng Li He-Ran Li Jian Zhang Dao-Feng Chen |
| author_facet | Qun Sun Nai-Yu Xu Qi-Run Li Shi Yao Meng Li He-Ran Li Jian Zhang Dao-Feng Chen |
| author_sort | Qun Sun |
| collection | DOAJ |
| description | Gnaphalium hypoleucum DC is used as a wild vegetable, named “Qing Ming Cai”, as well as a folk medicine in China. One new compound, Gnaphaliin C, and nineteen known compounds were isolated and indentified from G. hypoleucum, total flavonoids were analyzed by UHPLC-Q-TOF/MS. The α-glucosidase inhibitory and anti-complementary activities of all compounds and total flavonoids were evaluated. Total flavonoids and ten compounds exhibited anti-complementary activities. Total flavonoids and six compounds inhibited α-glucosidase. The antihyperglycaemic effects of total flavonoids were investigated by streptozotocin (STZ)-induced diabetic mice. Total flavonoids improved the glucose tolerance and decreased blood sugar, increased muscle glycogen content, decreased the levels of triacylglycerol (TG) and total cholesterol (TC), enhanced superoxide dismutase (SOD) activity and decreased malondialdehyde (MDA) level in diabetic mice. G. hypoleucum and its total flavonoids could be used as functional food for diabetics. |
| first_indexed | 2024-12-20T09:13:28Z |
| format | Article |
| id | doaj.art-9524b3a66ed74685a952353fc6f18977 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T09:13:28Z |
| publishDate | 2017-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-9524b3a66ed74685a952353fc6f189772022-12-21T19:45:28ZengElsevierJournal of Functional Foods1756-46462017-11-0138321328Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DCQun Sun0Nai-Yu Xu1Qi-Run Li2Shi Yao3Meng Li4He-Ran Li5Jian Zhang6Dao-Feng Chen7College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, ChinaCollege of Pharmaceutical Sciences, Soochow University, Suzhou 215123, ChinaCollege of Pharmaceutical Sciences, Soochow University, Suzhou 215123, ChinaCollege of Pharmaceutical Sciences, Soochow University, Suzhou 215123, ChinaCollege of Pharmaceutical Sciences, Soochow University, Suzhou 215123, ChinaCollege of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China; Corresponding authors.College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China; Corresponding authors.Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, ChinaGnaphalium hypoleucum DC is used as a wild vegetable, named “Qing Ming Cai”, as well as a folk medicine in China. One new compound, Gnaphaliin C, and nineteen known compounds were isolated and indentified from G. hypoleucum, total flavonoids were analyzed by UHPLC-Q-TOF/MS. The α-glucosidase inhibitory and anti-complementary activities of all compounds and total flavonoids were evaluated. Total flavonoids and ten compounds exhibited anti-complementary activities. Total flavonoids and six compounds inhibited α-glucosidase. The antihyperglycaemic effects of total flavonoids were investigated by streptozotocin (STZ)-induced diabetic mice. Total flavonoids improved the glucose tolerance and decreased blood sugar, increased muscle glycogen content, decreased the levels of triacylglycerol (TG) and total cholesterol (TC), enhanced superoxide dismutase (SOD) activity and decreased malondialdehyde (MDA) level in diabetic mice. G. hypoleucum and its total flavonoids could be used as functional food for diabetics.http://www.sciencedirect.com/science/article/pii/S1756464617305157Gnaphalium hypoleucum DCCompoundsTotal flavonoidsα-Glucosidase inhibitory activityAnticomplentary activityAntihyperglycaemic effect |
| spellingShingle | Qun Sun Nai-Yu Xu Qi-Run Li Shi Yao Meng Li He-Ran Li Jian Zhang Dao-Feng Chen Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DC Journal of Functional Foods Gnaphalium hypoleucum DC Compounds Total flavonoids α-Glucosidase inhibitory activity Anticomplentary activity Antihyperglycaemic effect |
| title | Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DC |
| title_full | Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DC |
| title_fullStr | Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DC |
| title_full_unstemmed | Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DC |
| title_short | Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DC |
| title_sort | antiglycemic and anticomplementary potential of an edible plant gnaphalium hypoleucum dc |
| topic | Gnaphalium hypoleucum DC Compounds Total flavonoids α-Glucosidase inhibitory activity Anticomplentary activity Antihyperglycaemic effect |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617305157 |
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