Remarkable Protective Effects of Nrf2-Mediated Antioxidant Enzymes and Tissue Specificity in Different Skeletal Muscles of Daurian Ground Squirrels Over the Torpor-Arousal Cycle

Remarkable Protective Effects of Nrf2-Mediated Antioxidant Enzymes and Tissue Specificity in Different Skeletal Muscles of Daurian Ground Squirrels Over the Torpor-Arousal Cycle

Hibernating mammals experience conditions of extreme oxidative stress, such as fasting, muscle disuse, and repeated hypoxic ischemia-reperfusion, during the torpor-arousal cycle. Despite this, they experience little oxidative injury and are thus an interesting model of anti-oxidative damage. Thus, i...

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Bibliographic Details
Main Authors: Yanhong Wei, Jie Zhang, Xia Yan, Xin Peng, Shenhui Xu, Hui Chang, Huiping Wang, Yunfang Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Physiology
Subjects:
hibernation
oxidative stress
antioxidant enzymes
Nrf2/Keap1 signaling pathway
skeletal muscle
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01449/full

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