The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis
Background: The rapid progression of Coronavirus disease 2019 (COVID-19) and its increasing burden on health systems necessitate the identification of parameters of severe infection to help in monitoring, prognoses and development of treatment algorithms. Objectives: This review aims to investigate...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Knowledge E
2020-04-01
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| Series: | Sudan Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/sjms.v15i5.7146 |
| _version_ | 1818642566466240512 |
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| author | Almigdad H. M. Ali Sagad Omer Obeid Mohamed Ibrahim H. E. Elkhidir Mohamed Elata Hassan Elbathani Abazr A. H. Ibrahim Almutasim B. E. Elhassan Mohammed Suliman Tawer Salman Mazin A.M. Elhassan Mahmoud Elnil Abdelhamid Ibrahim Hassan Abuzied |
| author_facet | Almigdad H. M. Ali Sagad Omer Obeid Mohamed Ibrahim H. E. Elkhidir Mohamed Elata Hassan Elbathani Abazr A. H. Ibrahim Almutasim B. E. Elhassan Mohammed Suliman Tawer Salman Mazin A.M. Elhassan Mahmoud Elnil Abdelhamid Ibrahim Hassan Abuzied |
| author_sort | Almigdad H. M. Ali |
| collection | DOAJ |
| description | Background: The rapid progression of Coronavirus disease 2019 (COVID-19) and its increasing burden on health systems necessitate the identification of parameters of severe infection to help in monitoring, prognoses and development of treatment algorithms.
Objectives: This review aims to investigate the association of lymphocyte count, CRP, LDH, and D-Dimer with the severity of COVID-19.
Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases of MEDLINE/PubMed, WHO-Virtual Health Library (VHL), and ScienceDirect were used for the systematic search. Random effects model was used to estimate the pooled standardized mean differences (SMD) with the corresponding 95% confidence interval (CI), using OpenMeta Analyst software.
Results: A total of 11 studies, with 2437 COVID-19 patients, which fulfilled the eligibility criteria were included in the meta-analysis. The analysis revealed that lymphocyte count was significantly lower in patients with the severe form of COVID-19 (SMD = - 1.025, P value <.001). Also, the analysis of SMD showed that patients with severe COVID-19 have a significantly higher serum levels of CRP (SMD = 3.363, P value <.001), D-Dimer (SMD = 1.073, P value <.001), and LDH (SMD = 3.345, P value <.001).
Conclusion: Low lymphocyte count and high levels of CRP, LDH, and D-Dimer are associated with severe COVID-19. These laboratory markers could be used as clinical indicators of worsening illness and poor prognosis of COVID-19. |
| first_indexed | 2024-12-16T23:45:06Z |
| format | Article |
| id | doaj.art-9527c97b0c07470baf4b3cdca30cc622 |
| institution | Directory Open Access Journal |
| issn | 1858-5051 |
| language | English |
| last_indexed | 2024-12-16T23:45:06Z |
| publishDate | 2020-04-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Sudan Journal of Medical Sciences |
| spelling | doaj.art-9527c97b0c07470baf4b3cdca30cc6222022-12-21T22:11:30ZengKnowledge ESudan Journal of Medical Sciences1858-50512020-04-011510.18502/sjms.v15i5.7146sjms.v15i5.7146The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-AnalysisAlmigdad H. M. Ali0Sagad Omer Obeid Mohamed1Ibrahim H. E. Elkhidir2Mohamed Elata Hassan Elbathani3Abazr A. H. Ibrahim4Almutasim B. E. Elhassan5Mohammed Suliman Tawer Salman6Mazin A.M. Elhassan7Mahmoud Elnil8Abdelhamid Ibrahim Hassan Abuzied9Faculty of Medicine, University of Khartoum, SudanFaculty of Medicine, University of Khartoum, SudanFaculty of Medicine, University of Khartoum, SudanFaculty of Medicine, University of Khartoum, SudanFaculty of Medicine, University of Khartoum, SudanFaculty of Medicine, University of Khartoum, SudanFaculty of Medicine, University of Khartoum, SudanFaculty of Medicine, University of Khartoum, SudanFaculty of Medicine, University of Khartoum, SudanFaculty of Medicine, University of Khartoum, SudanBackground: The rapid progression of Coronavirus disease 2019 (COVID-19) and its increasing burden on health systems necessitate the identification of parameters of severe infection to help in monitoring, prognoses and development of treatment algorithms. Objectives: This review aims to investigate the association of lymphocyte count, CRP, LDH, and D-Dimer with the severity of COVID-19. Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases of MEDLINE/PubMed, WHO-Virtual Health Library (VHL), and ScienceDirect were used for the systematic search. Random effects model was used to estimate the pooled standardized mean differences (SMD) with the corresponding 95% confidence interval (CI), using OpenMeta Analyst software. Results: A total of 11 studies, with 2437 COVID-19 patients, which fulfilled the eligibility criteria were included in the meta-analysis. The analysis revealed that lymphocyte count was significantly lower in patients with the severe form of COVID-19 (SMD = - 1.025, P value <.001). Also, the analysis of SMD showed that patients with severe COVID-19 have a significantly higher serum levels of CRP (SMD = 3.363, P value <.001), D-Dimer (SMD = 1.073, P value <.001), and LDH (SMD = 3.345, P value <.001). Conclusion: Low lymphocyte count and high levels of CRP, LDH, and D-Dimer are associated with severe COVID-19. These laboratory markers could be used as clinical indicators of worsening illness and poor prognosis of COVID-19.https://doi.org/10.18502/sjms.v15i5.7146covid-19, lymphocyte count, crp, d-dimer, ldh, meta-analysis |
| spellingShingle | Almigdad H. M. Ali Sagad Omer Obeid Mohamed Ibrahim H. E. Elkhidir Mohamed Elata Hassan Elbathani Abazr A. H. Ibrahim Almutasim B. E. Elhassan Mohammed Suliman Tawer Salman Mazin A.M. Elhassan Mahmoud Elnil Abdelhamid Ibrahim Hassan Abuzied The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis Sudan Journal of Medical Sciences covid-19, lymphocyte count, crp, d-dimer, ldh, meta-analysis |
| title | The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis |
| title_full | The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis |
| title_fullStr | The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis |
| title_full_unstemmed | The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis |
| title_short | The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis |
| title_sort | association of lymphocyte count crp d dimer and ldh with severe coronavirus disease 2019 covid 19 a meta analysis |
| topic | covid-19, lymphocyte count, crp, d-dimer, ldh, meta-analysis |
| url | https://doi.org/10.18502/sjms.v15i5.7146 |
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