Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control Study
Periprosthetic joint infections (PJIs) are a cause of frequent implant failure in revision hip replacement surgery. The purpose of this study is to evaluate the onset of early postoperative infections in patients who underwent hip surgery with cementless prostheses treated with an antibiotic loaded...
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MDPI AG
2020-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/4/571 |
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| author | Daniele De Meo Valeria Calogero Lorenzo Are Armando U. Cavallo Pietro Persiani Ciro Villani |
| author_facet | Daniele De Meo Valeria Calogero Lorenzo Are Armando U. Cavallo Pietro Persiani Ciro Villani |
| author_sort | Daniele De Meo |
| collection | DOAJ |
| description | Periprosthetic joint infections (PJIs) are a cause of frequent implant failure in revision hip replacement surgery. The purpose of this study is to evaluate the onset of early postoperative infections in patients who underwent hip surgery with cementless prostheses treated with an antibiotic loaded hydrogel on their surface, in addition to systemic prophylaxis, and compare them to a control group. The secondary objective was to evaluate the onset of any local and systemic adverse effects and interference with bone ingrowth processes and functional recovery. A retrospective observational study was conducted on patients who underwent revision hip surgery by performing a 1:1 match between patients treated with an antibiotic hydrogel (ALH) and the control patients. The incidence of PJIs was assessed with a minimum of six months follow-up. Seventeen patients treated with the ALH were compared with 17 patients from the control group. No PJIs were reported in the ALH group versus the six cases encountered in the control group (<i>p</i> < 0.0001). No significant differences were reported with regard to prosthetic osseointegration and functional results, nor were there side effects in the ALH group. Despite the low sample size, the use of on-site prophylaxis with ALH has proven effective and safe in reducing the risk of PJIs in patients with a high risk for infections. Further studies are needed to validate these results in other implant-related surgeries. |
| first_indexed | 2024-03-10T20:27:17Z |
| format | Article |
| id | doaj.art-9528c466156942bcb0ea485f14ca964d |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T20:27:17Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-9528c466156942bcb0ea485f14ca964d2023-11-19T21:42:50ZengMDPI AGMicroorganisms2076-26072020-04-018457110.3390/microorganisms8040571Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control StudyDaniele De Meo0Valeria Calogero1Lorenzo Are2Armando U. Cavallo3Pietro Persiani4Ciro Villani5Department of Orthopaedic and Traumatology, Policlinico Umberto I Hospital - Sapienza University of Rome, Piazzale A. Moro, 3, 00185 Rome, ItalyDepartment of Orthopaedic and Traumatology, Policlinico Umberto I Hospital - Sapienza University of Rome, Piazzale A. Moro, 3, 00185 Rome, ItalyDepartment of Orthopaedic and Traumatology, Policlinico Umberto I Hospital - Sapienza University of Rome, Piazzale A. Moro, 3, 00185 Rome, ItalyDepartment of Biomedicine and Prevention, Tor Vergata University, Via Cracovia, 50, 00133 Rome, ItalyDepartment of Orthopaedic and Traumatology, Policlinico Umberto I Hospital - Sapienza University of Rome, Piazzale A. Moro, 3, 00185 Rome, ItalyDepartment of Orthopaedic and Traumatology, Policlinico Umberto I Hospital - Sapienza University of Rome, Piazzale A. Moro, 3, 00185 Rome, ItalyPeriprosthetic joint infections (PJIs) are a cause of frequent implant failure in revision hip replacement surgery. The purpose of this study is to evaluate the onset of early postoperative infections in patients who underwent hip surgery with cementless prostheses treated with an antibiotic loaded hydrogel on their surface, in addition to systemic prophylaxis, and compare them to a control group. The secondary objective was to evaluate the onset of any local and systemic adverse effects and interference with bone ingrowth processes and functional recovery. A retrospective observational study was conducted on patients who underwent revision hip surgery by performing a 1:1 match between patients treated with an antibiotic hydrogel (ALH) and the control patients. The incidence of PJIs was assessed with a minimum of six months follow-up. Seventeen patients treated with the ALH were compared with 17 patients from the control group. No PJIs were reported in the ALH group versus the six cases encountered in the control group (<i>p</i> < 0.0001). No significant differences were reported with regard to prosthetic osseointegration and functional results, nor were there side effects in the ALH group. Despite the low sample size, the use of on-site prophylaxis with ALH has proven effective and safe in reducing the risk of PJIs in patients with a high risk for infections. Further studies are needed to validate these results in other implant-related surgeries.https://www.mdpi.com/2076-2607/8/4/571infectionbiofilmhydrogellocal antibioticsperiprosthetic joint infectionhip revision |
| spellingShingle | Daniele De Meo Valeria Calogero Lorenzo Are Armando U. Cavallo Pietro Persiani Ciro Villani Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control Study Microorganisms infection biofilm hydrogel local antibiotics periprosthetic joint infection hip revision |
| title | Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control Study |
| title_full | Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control Study |
| title_fullStr | Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control Study |
| title_full_unstemmed | Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control Study |
| title_short | Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control Study |
| title_sort | antibiotic loaded hydrogel coating to reduce early postsurgical infections in aseptic hip revision surgery a retrospective matched case control study |
| topic | infection biofilm hydrogel local antibiotics periprosthetic joint infection hip revision |
| url | https://www.mdpi.com/2076-2607/8/4/571 |
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