Orthobiologic Injections for the Treatment of Hip Osteoarthritis: A Systematic Review
The use of orthobiologics is gaining increasing interest as a minimally invasive treatment for hip osteoarthritis (OA). The aim of this study was to investigate the evidence about the safety and efficacy of these products. A systematic review of the literature was performed according to the PRISMA a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/22/6663 |
| _version_ | 1797464979803209728 |
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| author | Marco Zaffagnini Angelo Boffa Luca Andriolo Federico Raggi Stefano Zaffagnini Giuseppe Filardo |
| author_facet | Marco Zaffagnini Angelo Boffa Luca Andriolo Federico Raggi Stefano Zaffagnini Giuseppe Filardo |
| author_sort | Marco Zaffagnini |
| collection | DOAJ |
| description | The use of orthobiologics is gaining increasing interest as a minimally invasive treatment for hip osteoarthritis (OA). The aim of this study was to investigate the evidence about the safety and efficacy of these products. A systematic review of the literature was performed according to the PRISMA and Cochrane guidelines. The study quality was assessed using the RoB 2.0 for randomized controlled trials (RCTs) and the modified Coleman Methodology Score (mCMS) for all studies. A total of 20 clinical studies (735 patients) was identified, 12 on PRP injections and eight on cell-based therapies (five from bone marrow, two from adipose tissue, and one from amniotic fluid). The publication trend increased over time, with over 50% of articles published from 2019. The literature analysis showed only six RCTs, all on PRP injections. The mCMS showed an overall fair methodology (mean score 59.4). While the number of studies and their methodology are still limited, the available evidence suggests safety and overall promising results, with the treatment success being inversely proportional to the severity of OA. Further high-level controlled trials are needed before drawing more definitive conclusions on the real potential of orthobiologics for the injective treatment of patients affected by hip OA. |
| first_indexed | 2024-03-09T18:14:53Z |
| format | Article |
| id | doaj.art-952a017d634f4614a4ac011389323596 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:14:53Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-952a017d634f4614a4ac0113893235962023-11-24T08:48:00ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011122666310.3390/jcm11226663Orthobiologic Injections for the Treatment of Hip Osteoarthritis: A Systematic ReviewMarco Zaffagnini0Angelo Boffa1Luca Andriolo2Federico Raggi3Stefano Zaffagnini4Giuseppe Filardo5Clinica Ortopedica e Traumatologica 2, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyClinica Ortopedica e Traumatologica 2, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyClinica Ortopedica e Traumatologica 2, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyClinica Ortopedica e Traumatologica 2, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyClinica Ortopedica e Traumatologica 2, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyApplied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyThe use of orthobiologics is gaining increasing interest as a minimally invasive treatment for hip osteoarthritis (OA). The aim of this study was to investigate the evidence about the safety and efficacy of these products. A systematic review of the literature was performed according to the PRISMA and Cochrane guidelines. The study quality was assessed using the RoB 2.0 for randomized controlled trials (RCTs) and the modified Coleman Methodology Score (mCMS) for all studies. A total of 20 clinical studies (735 patients) was identified, 12 on PRP injections and eight on cell-based therapies (five from bone marrow, two from adipose tissue, and one from amniotic fluid). The publication trend increased over time, with over 50% of articles published from 2019. The literature analysis showed only six RCTs, all on PRP injections. The mCMS showed an overall fair methodology (mean score 59.4). While the number of studies and their methodology are still limited, the available evidence suggests safety and overall promising results, with the treatment success being inversely proportional to the severity of OA. Further high-level controlled trials are needed before drawing more definitive conclusions on the real potential of orthobiologics for the injective treatment of patients affected by hip OA.https://www.mdpi.com/2077-0383/11/22/6663osteoarthritishiporthobiologicsplatelet rich plasma (PRP)bone marrow aspirate concentrate (BMAC)micro-fragmented adipose tissue (MF-AT) |
| spellingShingle | Marco Zaffagnini Angelo Boffa Luca Andriolo Federico Raggi Stefano Zaffagnini Giuseppe Filardo Orthobiologic Injections for the Treatment of Hip Osteoarthritis: A Systematic Review Journal of Clinical Medicine osteoarthritis hip orthobiologics platelet rich plasma (PRP) bone marrow aspirate concentrate (BMAC) micro-fragmented adipose tissue (MF-AT) |
| title | Orthobiologic Injections for the Treatment of Hip Osteoarthritis: A Systematic Review |
| title_full | Orthobiologic Injections for the Treatment of Hip Osteoarthritis: A Systematic Review |
| title_fullStr | Orthobiologic Injections for the Treatment of Hip Osteoarthritis: A Systematic Review |
| title_full_unstemmed | Orthobiologic Injections for the Treatment of Hip Osteoarthritis: A Systematic Review |
| title_short | Orthobiologic Injections for the Treatment of Hip Osteoarthritis: A Systematic Review |
| title_sort | orthobiologic injections for the treatment of hip osteoarthritis a systematic review |
| topic | osteoarthritis hip orthobiologics platelet rich plasma (PRP) bone marrow aspirate concentrate (BMAC) micro-fragmented adipose tissue (MF-AT) |
| url | https://www.mdpi.com/2077-0383/11/22/6663 |
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