Pentoxifylline: A New Armamentarium in Diabetic Foot Ulcers
Background: Diabetic foot ulcers are estimated to affect 15% of all diabetics and precede almost 85% of foot amputations. Pentoxyfylline a substituted xanthenes’ derivative has been reported to increase the blood flow to the microcirculation and enhances tissue oxygenation. It has been widely us...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3984/24-7856_E(C)_F(T)_PF1(RKH)_PFA(H)_PFA2(H)_PF2(NJH)_PF2(NJH).pdf |
| Summary: | Background: Diabetic foot ulcers are estimated to affect 15%
of all diabetics and precede almost 85% of foot amputations.
Pentoxyfylline a substituted xanthenes’ derivative has been
reported to increase the blood flow to the microcirculation and
enhances tissue oxygenation. It has been widely used in the
treatment of intermittent claudication.
Materials and Methods: Pentoxyfylline is known to decrease
the rouleaux formation of RBC and hence helps in improving the
microcirculation. Out of 67 patients 30 received pentoxyfylline and
32 were on traditional treatment and there was loss of follow-up
in five cases.
The response was observed subjectively, histologically and by
Doppler studies.
Results: It was observed that the patients on pentoxyfylline had
early healing as compared to patients receiving only conventional
treatment as evident on biopsy and Doppler.
Conclusion: Here in this research our objective was to determine
whether pentoxyfylline (trental 400 mg) taken orally TDS in addition
to ambulatory compression bandages and dressings improves the
healing rates of diabetic ulcers. |
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| ISSN: | 2249-782X 0973-709X |