Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.

Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.

The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as a harmless commensal, but frequently causes infections under certain predisposing conditions. Translocation across the intestinal barrier into the bloodstream by intestine-colonizing C. albicans cells serves as t...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Jakob L Sprague, Tim B Schille, Stefanie Allert, Verena Trümper, Adrian Lier, Peter Großmann, Emily L Priest, Antzela Tsavou, Gianni Panagiotou, Julian R Naglik, Duncan Wilson, Sascha Schäuble, Lydia Kasper, Bernhard Hube
Format:	Article
Sprog:	English
Udgivet:	Public Library of Science (PLoS) 2024-03-01
Serier:	PLoS Pathogens
Online adgang:	https://doi.org/10.1371/journal.ppat.1012031

Lignende værker

<named-content content-type="genus-species">Candida albicans</named-content>-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers
af: Stefanie Allert, et al.
Udgivet: (2018-07-01)

Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity
af: Raquel Alonso-Roman, et al.
Udgivet: (2022-06-01)

Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis
af: Marisa Valentine, et al.
Udgivet: (2024-03-01)

The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage.
af: Duncan Wilson, et al.
Udgivet: (2016-10-01)

The Dual Function of the Fungal Toxin Candidalysin during <i>Candida albicans</i>—Macrophage Interaction and Virulence
af: Annika König, et al.
Udgivet: (2020-07-01)

Candida albicans Hap43 Domains Are Required under Iron Starvation but Not Excess
af: Volha Skrahina, et al.
Udgivet: (2017-12-01)

In Vivo Transcriptional Profiling of Human Pathogenic Fungi during Infection: Reflecting the Real Life?
af: Stefanie Allert, et al.
Udgivet: (2016-04-01)

Translocating the blood-brain barrier using electrostatics
af: Marta eRibeiro, et al.
Udgivet: (2012-10-01)

Shining a light on Candida-induced epithelial damage with a luciferase reporter
af: Millen Tesfamariam, et al.
Udgivet: (2024-11-01)

Candidalysin Is the Hemolytic Factor of <i>Candida albicans</i>
af: Selene Mogavero, et al.
Udgivet: (2022-12-01)

Candida albicans SR-Like Protein Kinases Regulate Different Cellular Processes: Sky1 Is Involved in Control of Ion Homeostasis, While Sky2 Is Important for Dipeptide Utilization
af: Philipp Brandt, et al.
Udgivet: (2022-05-01)

Bacterial translocation and barrier dysfunction enhance colonic tumorigenesis
af: Yongguo Zhang, et al.
Udgivet: (2023-01-01)

Mucosal Immunity and Candida albicans Infection
af: David L. Moyes, et al.
Udgivet: (2011-01-01)

Impairment of gut defense barrier and microbial translocation in HIV-infection
af: G. R. Khasanova
Udgivet: (2014-09-01)

Diffusion Limitations and Translocation Barriers in Atomically Thin Biomimetic Pores
af: Subin Sahu, et al.
Udgivet: (2020-11-01)

Assessment of an in vitro model of pulmonary barrier to study the translocation of nanoparticles
af: Samir Dekali, et al.
Udgivet: (2014-01-01)

Low potassium disrupt intestinal barrier and result in bacterial translocation
af: Haishan Wu, et al.
Udgivet: (2022-07-01)

Intestinal Infection of Candida albicans: Preventing the Formation of Biofilm by C. albicans and Protecting the Intestinal Epithelial Barrier
af: Ziyao Peng, et al.
Udgivet: (2022-02-01)

Regulatory networks controlling nitrogen sensing and uptake in Candida albicans.
af: Shruthi Ramachandra, et al.
Udgivet: (2014-01-01)

Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model
af: Katja Graf, et al.
Udgivet: (2019-09-01)

Candida albicans scavenges host zinc via Pra1 during endothelial invasion.
af: Francesco Citiulo, et al.
Udgivet: (2012-01-01)

Fabrication of nanoemulsion loaded with cefuroxime for efficient translocation across the blood brain barrier
af: Harun, Siti Norhawani
Udgivet: (2018)

Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy
af: Benjamin L. Franc, et al.
Udgivet: (2003-10-01)

Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers
af: Caroline A. de Jongh, et al.
Udgivet: (2023-12-01)

Intestinal Barrier Dysfunction and Microbial Translocation in Patients with First-Diagnosed Atrial Fibrillation
af: Leon Blöbaum, et al.
Udgivet: (2023-01-01)

Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries
af: Gabriela C Olivera, et al.
Udgivet: (2021-12-01)

Challenges in investigating “Gut barrier dysfunction and bacterial translocation in ICU-acquired bacteremia”
af: Luping Wang, et al.
Udgivet: (2024-05-01)

Albumin Neutralizes Hydrophobic Toxins and Modulates <i>Candida albicans</i> Pathogenicity
af: Sophie Austermeier, et al.
Udgivet: (2021-06-01)

A core filamentation response network in Candida albicans is restricted to eight genes.
af: Ronny Martin, et al.
Udgivet: (2013-01-01)

Mechanism for the Effect of Litsea cubeba Essential Oil on Candida albicans Cell Membrane Barrier
af: SUN Yue, ZENG Chaoyi, LI Ziyu, XIONG Haibo, LIN Zixi, CHE Zhenming, TANG Jie
Udgivet: (2023-09-01)

<i>Candida albicans</i> at Host Barrier Sites: Pattern Recognition Receptors and Beyond
af: Marc Swidergall
Udgivet: (2019-03-01)

Editorial: Metabolic barriers in cancer and cancer therapy
af: Sascha Kahlfuss, et al.
Udgivet: (2024-05-01)

A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis.
af: Junyan Liu, et al.
Udgivet: (2021-09-01)

Serial passaging of Candida albicans in systemic murine infection suggests that the wild type strain SC5314 is well adapted to the murine kidney.
af: Anja Lüttich, et al.
Udgivet: (2013-01-01)

Development, characterisation and translocation of valproic acid-encapsulated nanoemulsion across blood-brain barrier
af: Tan, Suk Fei
Udgivet: (2017)

ZINC AND CADMIUM IN TREE SPECIES OF FOREST ECOSYSTEMS: PATTERNS OF TRANSLOCATION, ACCUMULATION AND BARRIER MECHANISMS
af: O S Zheleznova, et al.
Udgivet: (2017-12-01)

Endotoxin Translocation and Gut Barrier Dysfunction Are Related to Variceal Bleeding in Patients With Liver Cirrhosis
af: Christos Triantos, et al.
Udgivet: (2022-03-01)

Salmonella Effector SpvB Disrupts Intestinal Epithelial Barrier Integrity for Bacterial Translocation
af: Lanqing Sun, et al.
Udgivet: (2020-12-01)

Health care providers’ perceptions of barriers to perinatal mental healthcare in South Africa
af: Shelley Brown, et al.
Udgivet: (2021-10-01)

Easier sieving through narrower pores: fluctuations and barrier crossing in flow-driven polymer translocation
af: Ledesma-Aguilar, R, et al.
Udgivet: (2012)