The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients
Gallbladder cancer (GBC) is an aggressive and highly lethal disease with relatively low global incidence, but one that constitutes a major health problem in Asian and Latin American countries, particularly in Chile. The identification of new tumor-associated markers with potential prognosis value is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/2/153 |
| _version_ | 1797408994701082624 |
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| author | Cristian Carrasco Andrés Tittarelli Natalia Paillaleve Maeva Del Pozo Daniel Rojas-Sepúlveda Omar Barría Paula Fluxá Melissa Hott Carolina Martin Claudia Quezada Flavio Salazar-Onfray |
| author_facet | Cristian Carrasco Andrés Tittarelli Natalia Paillaleve Maeva Del Pozo Daniel Rojas-Sepúlveda Omar Barría Paula Fluxá Melissa Hott Carolina Martin Claudia Quezada Flavio Salazar-Onfray |
| author_sort | Cristian Carrasco |
| collection | DOAJ |
| description | Gallbladder cancer (GBC) is an aggressive and highly lethal disease with relatively low global incidence, but one that constitutes a major health problem in Asian and Latin American countries, particularly in Chile. The identification of new tumor-associated markers with potential prognosis value is required for GBC clinical practice. Using immunohistochemistry/tumor tissue microarray, we evaluated the expression of 17 gastrointestinal tumor-associated protein markers (CK7, CK17, CK19, CK20, CKLMW, CKHMW, MUC1, MUC2, MUC5AC, MUC6, CA125, CD10, CEA, vimentin, villin, claudin-4, and CDX2) in primary gallbladder adenocarcinomas from 180 Chilean patients and analyzed potential associations with their pathological and clinical characteristics. Younger female patients with well- to moderately differentiated tumors had a better prognosis than that of older female or male patients with tumors with a similar tumor differentiation grade. Among all analyzed markers, MUC6 expression was associated with better prognosis in patients with well- to moderately differentiated tumors, whereas CK17 or CD10 was associated with worse prognosis in patients with poorly differentiated tumors. In addition, the MUC6<sup>+</sup>CK17<sup>–</sup> expression pattern was strongly associated with better prognosis in patients with well- to moderately differentiated tumors, whereas patients with poorly differentiated tumors and with the CK17<sup>+</sup>CD10<sup>+</sup> expression pattern showed worse prognosis. Our results suggest that tumor MUC6, CK17, and CD10 can be considered as potential prognosis markers for GBC. |
| first_indexed | 2024-03-09T04:07:53Z |
| format | Article |
| id | doaj.art-952d147dc67c4d41970346822d97a6a7 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T04:07:53Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-952d147dc67c4d41970346822d97a6a72023-12-03T14:04:39ZengMDPI AGDiagnostics2075-44182021-01-0111215310.3390/diagnostics11020153The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer PatientsCristian Carrasco0Andrés Tittarelli1Natalia Paillaleve2Maeva Del Pozo3Daniel Rojas-Sepúlveda4Omar Barría5Paula Fluxá6Melissa Hott7Carolina Martin8Claudia Quezada9Flavio Salazar-Onfray10Subdepartamento de Anatomía Patológica, Hospital Base de Valdivia, Valdivia 5090000, ChilePrograma Institucional de Fomento a la Investigación, Desarrollo e Innovación, Universidad Tecnológica Metropolitana, Santiago 8940577, ChileSubdepartamento de Anatomía Patológica, Hospital Base de Valdivia, Valdivia 5090000, ChileSubdepartamento de Anatomía Patológica, Hospital Base de Valdivia, Valdivia 5090000, ChileMillennium Institute on Immunology and Immunotherapy, Faculty of Medicine, Universidad de Chile, Santiago 8380453, ChileMillennium Institute on Immunology and Immunotherapy, Faculty of Medicine, Universidad de Chile, Santiago 8380453, ChileDepartamento de Cirugía Oriente, Facultad de Medicina, Universidad de Chile, Santiago 7500922, ChileSubdepartamento de Enfermedades Virales, Instituto de Salud Pública, Santiago 7780050, ChileEscuela de Tecnología Médica, Universidad Austral de Chile, Puerto Montt 5500000, ChileMillennium Institute on Immunology and Immunotherapy, Faculty of Medicine, Universidad de Chile, Santiago 8380453, ChileMillennium Institute on Immunology and Immunotherapy, Faculty of Medicine, Universidad de Chile, Santiago 8380453, ChileGallbladder cancer (GBC) is an aggressive and highly lethal disease with relatively low global incidence, but one that constitutes a major health problem in Asian and Latin American countries, particularly in Chile. The identification of new tumor-associated markers with potential prognosis value is required for GBC clinical practice. Using immunohistochemistry/tumor tissue microarray, we evaluated the expression of 17 gastrointestinal tumor-associated protein markers (CK7, CK17, CK19, CK20, CKLMW, CKHMW, MUC1, MUC2, MUC5AC, MUC6, CA125, CD10, CEA, vimentin, villin, claudin-4, and CDX2) in primary gallbladder adenocarcinomas from 180 Chilean patients and analyzed potential associations with their pathological and clinical characteristics. Younger female patients with well- to moderately differentiated tumors had a better prognosis than that of older female or male patients with tumors with a similar tumor differentiation grade. Among all analyzed markers, MUC6 expression was associated with better prognosis in patients with well- to moderately differentiated tumors, whereas CK17 or CD10 was associated with worse prognosis in patients with poorly differentiated tumors. In addition, the MUC6<sup>+</sup>CK17<sup>–</sup> expression pattern was strongly associated with better prognosis in patients with well- to moderately differentiated tumors, whereas patients with poorly differentiated tumors and with the CK17<sup>+</sup>CD10<sup>+</sup> expression pattern showed worse prognosis. Our results suggest that tumor MUC6, CK17, and CD10 can be considered as potential prognosis markers for GBC.https://www.mdpi.com/2075-4418/11/2/153gallbladder cancerprognosisbiomarkersmucin 6cytokeratin 17CD10 |
| spellingShingle | Cristian Carrasco Andrés Tittarelli Natalia Paillaleve Maeva Del Pozo Daniel Rojas-Sepúlveda Omar Barría Paula Fluxá Melissa Hott Carolina Martin Claudia Quezada Flavio Salazar-Onfray The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients Diagnostics gallbladder cancer prognosis biomarkers mucin 6 cytokeratin 17 CD10 |
| title | The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients |
| title_full | The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients |
| title_fullStr | The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients |
| title_full_unstemmed | The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients |
| title_short | The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients |
| title_sort | evaluation of 17 gastrointestinal tumor markers reveals prognosis value for muc6 ck17 and cd10 in gallbladder cancer patients |
| topic | gallbladder cancer prognosis biomarkers mucin 6 cytokeratin 17 CD10 |
| url | https://www.mdpi.com/2075-4418/11/2/153 |
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