RFID-Based Microwave Biosensor for Non-Contact Detection of Glucose Solution
Due to the increasing number of diabetic patients, early monitoring of glucose levels is particularly important; therefore, glucose biosensors have attracted enormous attention from researchers. In this paper, we propose a glucose microwave biosensor based on RFID and achieve a non-contact measureme...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/11/12/480 |
| _version_ | 1797506457431703552 |
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| author | Minjia Gao Tian Qiang Yangchuan Ma Junge Liang Yanfeng Jiang |
| author_facet | Minjia Gao Tian Qiang Yangchuan Ma Junge Liang Yanfeng Jiang |
| author_sort | Minjia Gao |
| collection | DOAJ |
| description | Due to the increasing number of diabetic patients, early monitoring of glucose levels is particularly important; therefore, glucose biosensors have attracted enormous attention from researchers. In this paper, we propose a glucose microwave biosensor based on RFID and achieve a non-contact measurement of the concentration of glucose solutions. The Reader is a complementary split-ring resonator (CSRR), and the Tag is comprised of a squared spiral capacitor (SSC). A polydimethylsiloxane microfluidic quantitative cavity with a volume of 1.56 μL is integrated on the Tag to ensure that the glucose solution can be accurately set to the sensitive area and fully contacted with the electromagnetic flux. Because the SSC exhibits different capacitances when it contacts glucose solutions of different concentrations, changing the resonant frequency of the CSRR, we can use the relationship to characterize the biosensing response. Measurement results show that bare CSRR and RFID-based biosensors have achieved sensitivities of 0.31 MHz/mg·dL<sup>−1</sup> and 10.27 kHz/mg·dL<sup>−1</sup>, and detection limits of 13.79 mg/dL and 1.19 mg/dL, respectively, and both realize a response time of less than 1 s. Linear regression analysis of the abovementioned biosensors showed an excellent linear relationship. The proposed design provides a feasible solution for microwave biosensors aiming for the non-contact measurement of glucose concentration. |
| first_indexed | 2024-03-10T04:32:56Z |
| format | Article |
| id | doaj.art-952fd934d5804562ac5dd48536c0a986 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T04:32:56Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-952fd934d5804562ac5dd48536c0a9862023-11-23T04:01:29ZengMDPI AGBiosensors2079-63742021-11-01111248010.3390/bios11120480RFID-Based Microwave Biosensor for Non-Contact Detection of Glucose SolutionMinjia Gao0Tian Qiang1Yangchuan Ma2Junge Liang3Yanfeng Jiang4Department of Electronic Engineering, School of Internet of Things Engineering, Jiangnan University, Wuxi 214122, ChinaDepartment of Electronic Engineering, School of Internet of Things Engineering, Jiangnan University, Wuxi 214122, ChinaDepartment of Electronic Engineering, School of Internet of Things Engineering, Jiangnan University, Wuxi 214122, ChinaDepartment of Electronic Engineering, School of Internet of Things Engineering, Jiangnan University, Wuxi 214122, ChinaDepartment of Electronic Engineering, School of Internet of Things Engineering, Jiangnan University, Wuxi 214122, ChinaDue to the increasing number of diabetic patients, early monitoring of glucose levels is particularly important; therefore, glucose biosensors have attracted enormous attention from researchers. In this paper, we propose a glucose microwave biosensor based on RFID and achieve a non-contact measurement of the concentration of glucose solutions. The Reader is a complementary split-ring resonator (CSRR), and the Tag is comprised of a squared spiral capacitor (SSC). A polydimethylsiloxane microfluidic quantitative cavity with a volume of 1.56 μL is integrated on the Tag to ensure that the glucose solution can be accurately set to the sensitive area and fully contacted with the electromagnetic flux. Because the SSC exhibits different capacitances when it contacts glucose solutions of different concentrations, changing the resonant frequency of the CSRR, we can use the relationship to characterize the biosensing response. Measurement results show that bare CSRR and RFID-based biosensors have achieved sensitivities of 0.31 MHz/mg·dL<sup>−1</sup> and 10.27 kHz/mg·dL<sup>−1</sup>, and detection limits of 13.79 mg/dL and 1.19 mg/dL, respectively, and both realize a response time of less than 1 s. Linear regression analysis of the abovementioned biosensors showed an excellent linear relationship. The proposed design provides a feasible solution for microwave biosensors aiming for the non-contact measurement of glucose concentration.https://www.mdpi.com/2079-6374/11/12/480RFIDnon-contact measurementmicrowave biosensorcomplementary split-ring resonatorglucose concentration |
| spellingShingle | Minjia Gao Tian Qiang Yangchuan Ma Junge Liang Yanfeng Jiang RFID-Based Microwave Biosensor for Non-Contact Detection of Glucose Solution Biosensors RFID non-contact measurement microwave biosensor complementary split-ring resonator glucose concentration |
| title | RFID-Based Microwave Biosensor for Non-Contact Detection of Glucose Solution |
| title_full | RFID-Based Microwave Biosensor for Non-Contact Detection of Glucose Solution |
| title_fullStr | RFID-Based Microwave Biosensor for Non-Contact Detection of Glucose Solution |
| title_full_unstemmed | RFID-Based Microwave Biosensor for Non-Contact Detection of Glucose Solution |
| title_short | RFID-Based Microwave Biosensor for Non-Contact Detection of Glucose Solution |
| title_sort | rfid based microwave biosensor for non contact detection of glucose solution |
| topic | RFID non-contact measurement microwave biosensor complementary split-ring resonator glucose concentration |
| url | https://www.mdpi.com/2079-6374/11/12/480 |
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