Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells. Here we show that androgen deprivation therapy (ADT), a...

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Bibliographic Details
Main Authors: Zuzana Pernicová, Eva Slabáková, Gvantsa Kharaishvili, Jan Bouchal, Milan Král, Zuzana Kunická, Miroslav Machala, Alois Kozubík, Karel Součcek
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800448

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