A fluorescently labelled quaternary ammonium compound (NBD-DDA) to study resistance mechanisms in bacteria

A fluorescently labelled quaternary ammonium compound (NBD-DDA) to study resistance mechanisms in bacteria

Quaternary ammonium compounds (QACs) are widely used as active agents in disinfectants, antiseptics, and preservatives. Despite being in use since the 1940s, there remain multiple open questions regarding their detailed mode-of-action and the mechanisms, including phenotypic heterogeneity, that can...

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Bibliographic Details
Main Authors: Niclas Nordholt, Kate O'Hara, Ute Resch-Genger, Mark A. T. Blaskovich, Bastian Rühle, Frank Schreiber
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Microbiology
Subjects:
quaternary ammonium compound
QAC
fluorescence
antimicrobial resistance
efflux
TolC
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1023326/full

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