Wnt Signaling in the Development of Bone Metastasis

Wnt signaling occurs through evolutionarily conserved pathways that affect cellular proliferation and fate decisions during development and tissue maintenance. Alterations in these highly regulated pathways, however, play pivotal roles in various malignancies, promoting cancer initiation, growth and...

Full description

Bibliographic Details
Main Authors: Noa Ben-Ghedalia-Peled, Razi Vago
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/11/23/3934
_version_ 1797463427933798400
author Noa Ben-Ghedalia-Peled
Razi Vago
author_facet Noa Ben-Ghedalia-Peled
Razi Vago
author_sort Noa Ben-Ghedalia-Peled
collection DOAJ
description Wnt signaling occurs through evolutionarily conserved pathways that affect cellular proliferation and fate decisions during development and tissue maintenance. Alterations in these highly regulated pathways, however, play pivotal roles in various malignancies, promoting cancer initiation, growth and metastasis and the development of drug resistance. The ability of cancer cells to metastasize is the primary cause of cancer mortality. Bone is one of the most frequent sites of metastases that generally arise from breast, prostate, lung, melanoma or kidney cancer. Upon their arrival to the bone, cancer cells can enter a long-term dormancy period, from which they can be reactivated, but can rarely be cured. The activation of Wnt signaling during the bone metastasis process was found to enhance proliferation, induce the epithelial-to-mesenchymal transition, promote the modulation of the extracellular matrix, enhance angiogenesis and immune tolerance and metastasize and thrive in the bone. Due to the complexity of Wnt pathways and of the landscape of this mineralized tissue, Wnt function during metastatic progression within bone is not yet fully understood. Therefore, we believe that a better understanding of these pathways and their roles in the development of bone metastasis could improve our understanding of the disease and may constitute fertile ground for potential therapeutics.
first_indexed 2024-03-09T17:50:34Z
format Article
id doaj.art-953258f7a4d04980b9675d4da5539f5e
institution Directory Open Access Journal
issn 2073-4409
language English
last_indexed 2024-03-09T17:50:34Z
publishDate 2022-12-01
publisher MDPI AG
record_format Article
series Cells
spelling doaj.art-953258f7a4d04980b9675d4da5539f5e2023-11-24T10:46:15ZengMDPI AGCells2073-44092022-12-011123393410.3390/cells11233934Wnt Signaling in the Development of Bone MetastasisNoa Ben-Ghedalia-Peled0Razi Vago1Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 8410501, IsraelAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 8410501, IsraelWnt signaling occurs through evolutionarily conserved pathways that affect cellular proliferation and fate decisions during development and tissue maintenance. Alterations in these highly regulated pathways, however, play pivotal roles in various malignancies, promoting cancer initiation, growth and metastasis and the development of drug resistance. The ability of cancer cells to metastasize is the primary cause of cancer mortality. Bone is one of the most frequent sites of metastases that generally arise from breast, prostate, lung, melanoma or kidney cancer. Upon their arrival to the bone, cancer cells can enter a long-term dormancy period, from which they can be reactivated, but can rarely be cured. The activation of Wnt signaling during the bone metastasis process was found to enhance proliferation, induce the epithelial-to-mesenchymal transition, promote the modulation of the extracellular matrix, enhance angiogenesis and immune tolerance and metastasize and thrive in the bone. Due to the complexity of Wnt pathways and of the landscape of this mineralized tissue, Wnt function during metastatic progression within bone is not yet fully understood. Therefore, we believe that a better understanding of these pathways and their roles in the development of bone metastasis could improve our understanding of the disease and may constitute fertile ground for potential therapeutics.https://www.mdpi.com/2073-4409/11/23/3934Wnt signalingβ-catenincancerbone metastasisosteolysisosteogenesis
spellingShingle Noa Ben-Ghedalia-Peled
Razi Vago
Wnt Signaling in the Development of Bone Metastasis
Cells
Wnt signaling
β-catenin
cancer
bone metastasis
osteolysis
osteogenesis
title Wnt Signaling in the Development of Bone Metastasis
title_full Wnt Signaling in the Development of Bone Metastasis
title_fullStr Wnt Signaling in the Development of Bone Metastasis
title_full_unstemmed Wnt Signaling in the Development of Bone Metastasis
title_short Wnt Signaling in the Development of Bone Metastasis
title_sort wnt signaling in the development of bone metastasis
topic Wnt signaling
β-catenin
cancer
bone metastasis
osteolysis
osteogenesis
url https://www.mdpi.com/2073-4409/11/23/3934
work_keys_str_mv AT noabenghedaliapeled wntsignalinginthedevelopmentofbonemetastasis
AT razivago wntsignalinginthedevelopmentofbonemetastasis