Venous thromboembolism risk, prophylaxis and management in cancer patients with COVID-19: An unmet medical need
Cancer patients exhibit an increased risk of venous thromboembolism (VTE), with VTE being the second leading cause of morbidity and mortality in these patients. The implementation of lockdowns following the COVID-19 pandemic has resulted in decreased mobility and delayed access to care, thus further...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Thrombosis Update |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666572722000025 |
| _version_ | 1819104316576759808 |
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| author | Benjamin Brenner Cihan Ay Grégoire Le Gal Marc Carrier Andrés J. Muñoz Giancarlo Agnelli Ana Thereza Cavalcanti Rocha Hikmat Abdel-Razeq Ismail Elalamy Anna Falanga |
| author_facet | Benjamin Brenner Cihan Ay Grégoire Le Gal Marc Carrier Andrés J. Muñoz Giancarlo Agnelli Ana Thereza Cavalcanti Rocha Hikmat Abdel-Razeq Ismail Elalamy Anna Falanga |
| author_sort | Benjamin Brenner |
| collection | DOAJ |
| description | Cancer patients exhibit an increased risk of venous thromboembolism (VTE), with VTE being the second leading cause of morbidity and mortality in these patients. The implementation of lockdowns following the COVID-19 pandemic has resulted in decreased mobility and delayed access to care, thus further increasing the susceptibility to VTE. Cancer patients may also be at a higher risk of SARS-CoV-2 infection and have been shown to be more likely to experience severe COVID-19 disease compared to patients without cancer. Given that both cancer and COVID-19 exhibit a hypercoagulable state, stasis of blood flow, and endothelial injury, cancer patients with COVID-19 constitute a vulnerable population with a high risk of thrombosis and bleeding. However, to date there are limited studies evaluating whether cancer patients infected with SARS-CoV-2 have a higher VTE incidence than COVID-19 patients without cancer, how to assess the risk of VTE, prophylaxis and treatment in this special population. Herein, we highlight the urgent need for studies in cancer patients with COVID-19 to ensure appropriate patient care and improve clinical outcomes. |
| first_indexed | 2024-12-22T02:04:25Z |
| format | Article |
| id | doaj.art-9532fbf0a66f420bab398ae7f5ef35da |
| institution | Directory Open Access Journal |
| issn | 2666-5727 |
| language | English |
| last_indexed | 2024-12-22T02:04:25Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Thrombosis Update |
| spelling | doaj.art-9532fbf0a66f420bab398ae7f5ef35da2022-12-21T18:42:33ZengElsevierThrombosis Update2666-57272022-03-016100098Venous thromboembolism risk, prophylaxis and management in cancer patients with COVID-19: An unmet medical needBenjamin Brenner0Cihan Ay1Grégoire Le Gal2Marc Carrier3Andrés J. Muñoz4Giancarlo Agnelli5Ana Thereza Cavalcanti Rocha6Hikmat Abdel-Razeq7Ismail Elalamy8Anna Falanga9Department of Hematology, Rambam Health Care Campus, Haifa, Israel; Department of Obstetrics and Gynaecology, The First I.M. Sechenov Moscow State Medical University, Moscow, Russia; Corresponding author. Benjamin Brenner Department of Hematology, Rambam Health Care Campus, Haifa, Israel.Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Comprehensive Cancer Vienna, Medical University of Vienna, Vienna, Austria; Department of Obstetrics and Gynaecology, The First I.M. Sechenov Moscow State Medical University, Moscow, RussiaDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, CanadaDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, CanadaMedical Oncology Department. Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, SpainInternal Vascular and Emergency Medicine – Stroke Unit, University of Perugia, Perugia, ItalyUniversidade Federal da Bahia – UFBA, Faculdade de Medicina da Bahia, Departamento de Saúde da FamíliaSalvador, BA, BrazilKing Hussein Cancer Centre, University of Jordan, Amman-Jordan, JordanHematology and Thrombosis Centre, Hôpital Tenon, INSERM U938, Sorbonne Université, AP-HP, Paris, France; Department of Obstetrics and Gynaecology, The First I.M. Sechenov Moscow State Medical University, Moscow, RussiaUniversity of Milano-Bicocca, School of Medicine, Monza, Italy; Department of Immunohematology and Transfusion Medicine, Thrombosis and Hemostasis Center, Hospital Papa Giovanni XXIII, Bergamo, ItalyCancer patients exhibit an increased risk of venous thromboembolism (VTE), with VTE being the second leading cause of morbidity and mortality in these patients. The implementation of lockdowns following the COVID-19 pandemic has resulted in decreased mobility and delayed access to care, thus further increasing the susceptibility to VTE. Cancer patients may also be at a higher risk of SARS-CoV-2 infection and have been shown to be more likely to experience severe COVID-19 disease compared to patients without cancer. Given that both cancer and COVID-19 exhibit a hypercoagulable state, stasis of blood flow, and endothelial injury, cancer patients with COVID-19 constitute a vulnerable population with a high risk of thrombosis and bleeding. However, to date there are limited studies evaluating whether cancer patients infected with SARS-CoV-2 have a higher VTE incidence than COVID-19 patients without cancer, how to assess the risk of VTE, prophylaxis and treatment in this special population. Herein, we highlight the urgent need for studies in cancer patients with COVID-19 to ensure appropriate patient care and improve clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2666572722000025COVID-19CoagulopathyCancerVTEThromboprophylaxis |
| spellingShingle | Benjamin Brenner Cihan Ay Grégoire Le Gal Marc Carrier Andrés J. Muñoz Giancarlo Agnelli Ana Thereza Cavalcanti Rocha Hikmat Abdel-Razeq Ismail Elalamy Anna Falanga Venous thromboembolism risk, prophylaxis and management in cancer patients with COVID-19: An unmet medical need Thrombosis Update COVID-19 Coagulopathy Cancer VTE Thromboprophylaxis |
| title | Venous thromboembolism risk, prophylaxis and management in cancer patients with COVID-19: An unmet medical need |
| title_full | Venous thromboembolism risk, prophylaxis and management in cancer patients with COVID-19: An unmet medical need |
| title_fullStr | Venous thromboembolism risk, prophylaxis and management in cancer patients with COVID-19: An unmet medical need |
| title_full_unstemmed | Venous thromboembolism risk, prophylaxis and management in cancer patients with COVID-19: An unmet medical need |
| title_short | Venous thromboembolism risk, prophylaxis and management in cancer patients with COVID-19: An unmet medical need |
| title_sort | venous thromboembolism risk prophylaxis and management in cancer patients with covid 19 an unmet medical need |
| topic | COVID-19 Coagulopathy Cancer VTE Thromboprophylaxis |
| url | http://www.sciencedirect.com/science/article/pii/S2666572722000025 |
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