Characterization of DAG Binding to TRPC Channels by Target-Dependent <i>cis–trans</i> Isomerization of OptoDArG

Characterization of DAG Binding to TRPC Channels by Target-Dependent <i>cis–trans</i> Isomerization of OptoDArG

Azobenzene-based photochromic lipids are valuable probes for the analysis of ion channel–lipid interactions. Rapid photoisomerization of these molecules enables the analysis of lipid gating kinetics and provides information on lipid sensing. Thermal relaxation of the metastable <i>cis</i>...

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Bibliographic Details
Main Authors: Hazel Erkan-Candag, Denis Krivic, Mathias A. F. Gsell, Mina Aleksanyan, Thomas Stockner, Rumiana Dimova, Oleksandra Tiapko, Klaus Groschner
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomolecules
Subjects:
lipid photopharmacology
TRPC channels
diacylglycerols
photoisomerization
Online Access:https://www.mdpi.com/2218-273X/12/6/799

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