STUDIES ON PROTECTIVE EFFECTS OF A VACCINE, BASED ON RECOMBINANT Ag85, TB10 AND FliC PROTEINS
At present time, there is an obvious need for a new generation of vaccines as the most effective preventive approach, in order to stop spreading of tuberculosis infection. So far, the most popular strategy is aimed at heterological vaccination. The idea is to use BCG, or improved BCG, or attenuated...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2017-05-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1223 |
| _version_ | 1797197961188343808 |
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| author | V. V. Yeremeev I. V. Duhovlinov A. I. Orlov A. F. Malenko E. A. Fedorova M. B. Balazovsky V. Ya. Gergert |
| author_facet | V. V. Yeremeev I. V. Duhovlinov A. I. Orlov A. F. Malenko E. A. Fedorova M. B. Balazovsky V. Ya. Gergert |
| author_sort | V. V. Yeremeev |
| collection | DOAJ |
| description | At present time, there is an obvious need for a new generation of vaccines as the most effective preventive approach, in order to stop spreading of tuberculosis infection. So far, the most popular strategy is aimed at heterological vaccination. The idea is to use BCG, or improved BCG, or attenuated M. tuberculosis for primary vaccination. For the further booster vaccination one may apply thw s.c. subunit or vector vaccines, containing protective mycobacterial proteins. The aim of our investigation was to evaluate protective effects of a new vaccine based on recombinant bacterial proteins Ag85, ТВ10 and FliC. We used a model with aerosol M. tuberculosis H37Rv infection, and compared lung and spleen CFU counts and life-span of vaccinated versus non-vaccinated С57BL/6 mice. As a result, we revealed three vaccine variants with comparable protective capacity against BCG using our experimental model. The most promising variant is suggested for testing in preclinical trials. |
| first_indexed | 2024-03-08T05:49:54Z |
| format | Article |
| id | doaj.art-9534a35afe534c619ea142582505b590 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:52:17Z |
| publishDate | 2017-05-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-9534a35afe534c619ea142582505b5902024-04-22T13:07:41ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2017-05-0119219720210.15789/1563-0625-2017-2-197-202895STUDIES ON PROTECTIVE EFFECTS OF A VACCINE, BASED ON RECOMBINANT Ag85, TB10 AND FliC PROTEINSV. V. Yeremeev0I. V. Duhovlinov1A. I. Orlov2A. F. Malenko3E. A. Fedorova4M. B. Balazovsky5V. Ya. Gergert6Central Tuberculosis Research Institute, MoscowResearch Institute of Experimental Medicine, St. PetersburgResearch Institute of Experimental Medicine, St. PetersburgCentral Tuberculosis Research Institute, MoscowResearch Institute of Experimental Medicine, St. PetersburgPharma VAM Private Company, St. PetersburgCentral Tuberculosis Research Institute, MoscowAt present time, there is an obvious need for a new generation of vaccines as the most effective preventive approach, in order to stop spreading of tuberculosis infection. So far, the most popular strategy is aimed at heterological vaccination. The idea is to use BCG, or improved BCG, or attenuated M. tuberculosis for primary vaccination. For the further booster vaccination one may apply thw s.c. subunit or vector vaccines, containing protective mycobacterial proteins. The aim of our investigation was to evaluate protective effects of a new vaccine based on recombinant bacterial proteins Ag85, ТВ10 and FliC. We used a model with aerosol M. tuberculosis H37Rv infection, and compared lung and spleen CFU counts and life-span of vaccinated versus non-vaccinated С57BL/6 mice. As a result, we revealed three vaccine variants with comparable protective capacity against BCG using our experimental model. The most promising variant is suggested for testing in preclinical trials.https://www.mimmun.ru/mimmun/article/view/1223tuberculosisvaccineimmunityrecombinant antigensprotectionmycobacterium |
| spellingShingle | V. V. Yeremeev I. V. Duhovlinov A. I. Orlov A. F. Malenko E. A. Fedorova M. B. Balazovsky V. Ya. Gergert STUDIES ON PROTECTIVE EFFECTS OF A VACCINE, BASED ON RECOMBINANT Ag85, TB10 AND FliC PROTEINS Медицинская иммунология tuberculosis vaccine immunity recombinant antigens protection mycobacterium |
| title | STUDIES ON PROTECTIVE EFFECTS OF A VACCINE, BASED ON RECOMBINANT Ag85, TB10 AND FliC PROTEINS |
| title_full | STUDIES ON PROTECTIVE EFFECTS OF A VACCINE, BASED ON RECOMBINANT Ag85, TB10 AND FliC PROTEINS |
| title_fullStr | STUDIES ON PROTECTIVE EFFECTS OF A VACCINE, BASED ON RECOMBINANT Ag85, TB10 AND FliC PROTEINS |
| title_full_unstemmed | STUDIES ON PROTECTIVE EFFECTS OF A VACCINE, BASED ON RECOMBINANT Ag85, TB10 AND FliC PROTEINS |
| title_short | STUDIES ON PROTECTIVE EFFECTS OF A VACCINE, BASED ON RECOMBINANT Ag85, TB10 AND FliC PROTEINS |
| title_sort | studies on protective effects of a vaccine based on recombinant ag85 tb10 and flic proteins |
| topic | tuberculosis vaccine immunity recombinant antigens protection mycobacterium |
| url | https://www.mimmun.ru/mimmun/article/view/1223 |
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