Exploring the role of FBXO5 in gastric cancer
Gastric cancer is one of the most common lethal malignancies in the world, especially in China. Due to the ineffective screening of early gastric cancer and drug resistance of the advanced, the prognosis of gastric cancer remains dismal. Based on bioinformatics and tissue microarray analyses, FBXO5...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Molecular and Cellular Probes |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0890850823000245 |
| _version_ | 1797788473092997120 |
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| author | Junchang Zhang Gengyuan Zhang Keshen Wang Feng Cui Hanteng Yang Zuoyi Jiao |
| author_facet | Junchang Zhang Gengyuan Zhang Keshen Wang Feng Cui Hanteng Yang Zuoyi Jiao |
| author_sort | Junchang Zhang |
| collection | DOAJ |
| description | Gastric cancer is one of the most common lethal malignancies in the world, especially in China. Due to the ineffective screening of early gastric cancer and drug resistance of the advanced, the prognosis of gastric cancer remains dismal. Based on bioinformatics and tissue microarray analyses, FBXO5 was selected for analysis in this study. Here, we report the function of FBXO5 in gastric cancer, showing for the first time that it contributes to tumor cell proliferation, clone formation, invasion and migration. In these preliminary findings, FBXO5 promoted the transition of the cell cycle from the G0/G1 to the G2/M phase, which likely resulted from FBXO5 interacting with CDK1 and NCAPG proteins. The relevant mechanism needs to be explored. In addition, FBXO5 participated in the tumor microenvironment and was negatively related to immune activation. FBXO5, an oncogene, plays a role in tumor initiation and progression, and is expected to be a potential target for gastric cancer treatment. |
| first_indexed | 2024-03-13T01:37:03Z |
| format | Article |
| id | doaj.art-953500f3a70f482a9e5737585f439c5b |
| institution | Directory Open Access Journal |
| issn | 0890-8508 |
| language | English |
| last_indexed | 2024-03-13T01:37:03Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular and Cellular Probes |
| spelling | doaj.art-953500f3a70f482a9e5737585f439c5b2023-07-04T05:09:10ZengElsevierMolecular and Cellular Probes0890-85082023-06-0169101915Exploring the role of FBXO5 in gastric cancerJunchang Zhang0Gengyuan Zhang1Keshen Wang2Feng Cui3Hanteng Yang4Zuoyi Jiao5Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, ChinaCorresponding author.; Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, ChinaCorresponding author.; Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, ChinaGastric cancer is one of the most common lethal malignancies in the world, especially in China. Due to the ineffective screening of early gastric cancer and drug resistance of the advanced, the prognosis of gastric cancer remains dismal. Based on bioinformatics and tissue microarray analyses, FBXO5 was selected for analysis in this study. Here, we report the function of FBXO5 in gastric cancer, showing for the first time that it contributes to tumor cell proliferation, clone formation, invasion and migration. In these preliminary findings, FBXO5 promoted the transition of the cell cycle from the G0/G1 to the G2/M phase, which likely resulted from FBXO5 interacting with CDK1 and NCAPG proteins. The relevant mechanism needs to be explored. In addition, FBXO5 participated in the tumor microenvironment and was negatively related to immune activation. FBXO5, an oncogene, plays a role in tumor initiation and progression, and is expected to be a potential target for gastric cancer treatment.http://www.sciencedirect.com/science/article/pii/S0890850823000245Gastric cancerFBXO5Cell cycle |
| spellingShingle | Junchang Zhang Gengyuan Zhang Keshen Wang Feng Cui Hanteng Yang Zuoyi Jiao Exploring the role of FBXO5 in gastric cancer Molecular and Cellular Probes Gastric cancer FBXO5 Cell cycle |
| title | Exploring the role of FBXO5 in gastric cancer |
| title_full | Exploring the role of FBXO5 in gastric cancer |
| title_fullStr | Exploring the role of FBXO5 in gastric cancer |
| title_full_unstemmed | Exploring the role of FBXO5 in gastric cancer |
| title_short | Exploring the role of FBXO5 in gastric cancer |
| title_sort | exploring the role of fbxo5 in gastric cancer |
| topic | Gastric cancer FBXO5 Cell cycle |
| url | http://www.sciencedirect.com/science/article/pii/S0890850823000245 |
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