Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion
FOXP1 is ubiquitously expressed in the human body and is implicated in both physiological and pathological processes including cancer. However, despite its importance the role of FOXP1 in T-cells has not been extensively studied. Although relatively few phenotypic and mechanistic details are availab...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.971045/full |
| _version_ | 1811205572546002944 |
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| author | Yaroslav Kaminskiy Yaroslav Kaminskiy Varvara Kuznetsova Anna Kudriaeva Ekaterina Zmievskaya Emil Bulatov Emil Bulatov |
| author_facet | Yaroslav Kaminskiy Yaroslav Kaminskiy Varvara Kuznetsova Anna Kudriaeva Ekaterina Zmievskaya Emil Bulatov Emil Bulatov |
| author_sort | Yaroslav Kaminskiy |
| collection | DOAJ |
| description | FOXP1 is ubiquitously expressed in the human body and is implicated in both physiological and pathological processes including cancer. However, despite its importance the role of FOXP1 in T-cells has not been extensively studied. Although relatively few phenotypic and mechanistic details are available, FOXP1 role in T-cell quiescence and differentiation of CD4+ subsets has recently been established. FOXP1 prevents spontaneous T-cell activation, preserves memory potential, and regulates the development of follicular helper and regulatory T-cells. Moreover, there is growing evidence that FOXP1 also regulates T-cell exhaustion. Altogether this makes FOXP1 a crucial and highly undervalued regulator of T-cell homeostasis. In this review, we discuss the biology of FOXP1 with a focus on discoveries made in T-cells in recent years. |
| first_indexed | 2024-04-12T03:34:41Z |
| format | Article |
| id | doaj.art-95353c74a5cb4f27b978109b5c8e2ea5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T03:34:41Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-95353c74a5cb4f27b978109b5c8e2ea52022-12-22T03:49:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.971045971045Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustionYaroslav Kaminskiy0Yaroslav Kaminskiy1Varvara Kuznetsova2Anna Kudriaeva3Ekaterina Zmievskaya4Emil Bulatov5Emil Bulatov6Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, SwedenLaboratory of Transplantation Immunology, National Research Centre for Hematology, Moscow, RussiaLaboratory of Transplantation Immunology, National Research Centre for Hematology, Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, RussiaFOXP1 is ubiquitously expressed in the human body and is implicated in both physiological and pathological processes including cancer. However, despite its importance the role of FOXP1 in T-cells has not been extensively studied. Although relatively few phenotypic and mechanistic details are available, FOXP1 role in T-cell quiescence and differentiation of CD4+ subsets has recently been established. FOXP1 prevents spontaneous T-cell activation, preserves memory potential, and regulates the development of follicular helper and regulatory T-cells. Moreover, there is growing evidence that FOXP1 also regulates T-cell exhaustion. Altogether this makes FOXP1 a crucial and highly undervalued regulator of T-cell homeostasis. In this review, we discuss the biology of FOXP1 with a focus on discoveries made in T-cells in recent years.https://www.frontiersin.org/articles/10.3389/fimmu.2022.971045/fullFoxP1T cellTregquiescenceT cell differentiationisoforms |
| spellingShingle | Yaroslav Kaminskiy Yaroslav Kaminskiy Varvara Kuznetsova Anna Kudriaeva Ekaterina Zmievskaya Emil Bulatov Emil Bulatov Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion Frontiers in Immunology FoxP1 T cell Treg quiescence T cell differentiation isoforms |
| title | Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion |
| title_full | Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion |
| title_fullStr | Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion |
| title_full_unstemmed | Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion |
| title_short | Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion |
| title_sort | neglected yet significant role of foxp1 in t cell quiescence differentiation and exhaustion |
| topic | FoxP1 T cell Treg quiescence T cell differentiation isoforms |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.971045/full |
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