Altered serum uric acid level in lichen planus patients
Background: Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear. Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP. Objectives: The principal aim of this study was to evaluate serum uric acid (U...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2014;volume=59;issue=6;spage=558;epage=561;aulast=Chakraborti |
| _version_ | 1811213074726649856 |
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| author | Goutam Chakraborti Rabindranath Biswas Sandip Chakraborti Pradyot Kumar Sen |
| author_facet | Goutam Chakraborti Rabindranath Biswas Sandip Chakraborti Pradyot Kumar Sen |
| author_sort | Goutam Chakraborti |
| collection | DOAJ |
| description | Background: Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear. Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP. Objectives: The principal aim of this study was to evaluate serum uric acid (UA) levels as a measure of the antioxidant defense status in LP patients. Methods: Serum UA levels were determined in 58 LP patients and 61 controls. Results: Serum UA levels were significantly decreased in patients with respect to controls. Moreover, serum UA level was decreased according to increasing duration of disease. Conclusions: The results of our study suggest that LP is associated with decrease of UA levels in serum. UA may be a potential, useful biomarker of antioxidant status in LP for elaboration of treatment strategy and monitoring. |
| first_indexed | 2024-04-12T05:40:06Z |
| format | Article |
| id | doaj.art-9536ea49b0d74252830640cc7684f520 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-04-12T05:40:06Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-9536ea49b0d74252830640cc7684f5202022-12-22T03:45:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112014-01-0159655856110.4103/0019-5154.143510Altered serum uric acid level in lichen planus patientsGoutam ChakrabortiRabindranath BiswasSandip ChakrabortiPradyot Kumar SenBackground: Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear. Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP. Objectives: The principal aim of this study was to evaluate serum uric acid (UA) levels as a measure of the antioxidant defense status in LP patients. Methods: Serum UA levels were determined in 58 LP patients and 61 controls. Results: Serum UA levels were significantly decreased in patients with respect to controls. Moreover, serum UA level was decreased according to increasing duration of disease. Conclusions: The results of our study suggest that LP is associated with decrease of UA levels in serum. UA may be a potential, useful biomarker of antioxidant status in LP for elaboration of treatment strategy and monitoring.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2014;volume=59;issue=6;spage=558;epage=561;aulast=ChakrabortiAntioxidantfree radicallichen planusoxidative stressuric acid |
| spellingShingle | Goutam Chakraborti Rabindranath Biswas Sandip Chakraborti Pradyot Kumar Sen Altered serum uric acid level in lichen planus patients Indian Journal of Dermatology Antioxidant free radical lichen planus oxidative stress uric acid |
| title | Altered serum uric acid level in lichen planus patients |
| title_full | Altered serum uric acid level in lichen planus patients |
| title_fullStr | Altered serum uric acid level in lichen planus patients |
| title_full_unstemmed | Altered serum uric acid level in lichen planus patients |
| title_short | Altered serum uric acid level in lichen planus patients |
| title_sort | altered serum uric acid level in lichen planus patients |
| topic | Antioxidant free radical lichen planus oxidative stress uric acid |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2014;volume=59;issue=6;spage=558;epage=561;aulast=Chakraborti |
| work_keys_str_mv | AT goutamchakraborti alteredserumuricacidlevelinlichenplanuspatients AT rabindranathbiswas alteredserumuricacidlevelinlichenplanuspatients AT sandipchakraborti alteredserumuricacidlevelinlichenplanuspatients AT pradyotkumarsen alteredserumuricacidlevelinlichenplanuspatients |