Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases
Calcium phosphate is attracting attention as a bone repair material and a controlled-release carrier of various drugs such as bone disease therapeutic agents and anticancer agents. Compared with some bioabsorbable polymers, calcium phosphates have the advantage of preventing a pH decrease in the sur...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
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| Series: | Ceramics |
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| Online Access: | https://www.mdpi.com/2571-6131/4/2/23 |
| _version_ | 1827690510370734080 |
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| author | Toshiki Miyazaki Koudai Masuda Kazuki Sakamoto |
| author_facet | Toshiki Miyazaki Koudai Masuda Kazuki Sakamoto |
| author_sort | Toshiki Miyazaki |
| collection | DOAJ |
| description | Calcium phosphate is attracting attention as a bone repair material and a controlled-release carrier of various drugs such as bone disease therapeutic agents and anticancer agents. Compared with some bioabsorbable polymers, calcium phosphates have the advantage of preventing a pH decrease in the surrounding body fluid. However, there are few studies comparing the effect of supporting substances with different physicochemical properties on the production of calcium phosphate microspheres with different crystalline phases. In this study, we investigated conditions for obtaining low crystallinity apatite and octacalcium phosphate (OCP) microspheres from calcium carbonate microspheres with different crystalline structures using a simple phosphoric acid treatment. Furthermore, we investigated the adsorption and release behavior of different dyes and proteins from the apatite and OCP microspheres. Overall, the factors governing the adsorption and release behavior are different depending on the molecular size and surface charge of the dye and protein adsorbates. |
| first_indexed | 2024-03-10T10:40:11Z |
| format | Article |
| id | doaj.art-9537d0fd4ea64bb9a21b143b729f6893 |
| institution | Directory Open Access Journal |
| issn | 2571-6131 |
| language | English |
| last_indexed | 2024-03-10T10:40:11Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Ceramics |
| spelling | doaj.art-9537d0fd4ea64bb9a21b143b729f68932023-11-21T22:59:40ZengMDPI AGCeramics2571-61312021-06-014229130110.3390/ceramics4020023Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline PhasesToshiki Miyazaki0Koudai Masuda1Kazuki Sakamoto2Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, JapanGraduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, JapanGraduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, JapanCalcium phosphate is attracting attention as a bone repair material and a controlled-release carrier of various drugs such as bone disease therapeutic agents and anticancer agents. Compared with some bioabsorbable polymers, calcium phosphates have the advantage of preventing a pH decrease in the surrounding body fluid. However, there are few studies comparing the effect of supporting substances with different physicochemical properties on the production of calcium phosphate microspheres with different crystalline phases. In this study, we investigated conditions for obtaining low crystallinity apatite and octacalcium phosphate (OCP) microspheres from calcium carbonate microspheres with different crystalline structures using a simple phosphoric acid treatment. Furthermore, we investigated the adsorption and release behavior of different dyes and proteins from the apatite and OCP microspheres. Overall, the factors governing the adsorption and release behavior are different depending on the molecular size and surface charge of the dye and protein adsorbates.https://www.mdpi.com/2571-6131/4/2/23apatiteoctacalcium phosphate (OCP)microspheredrug deliverydyeprotein |
| spellingShingle | Toshiki Miyazaki Koudai Masuda Kazuki Sakamoto Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases Ceramics apatite octacalcium phosphate (OCP) microsphere drug delivery dye protein |
| title | Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases |
| title_full | Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases |
| title_fullStr | Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases |
| title_full_unstemmed | Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases |
| title_short | Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases |
| title_sort | release profiles of dyes and proteins from calcium phosphate microspheres with different crystalline phases |
| topic | apatite octacalcium phosphate (OCP) microsphere drug delivery dye protein |
| url | https://www.mdpi.com/2571-6131/4/2/23 |
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