Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration
Dimitrios Karagiannis,1 Irini Chatziralli,1 Konstantinos Kaprinis,1 Ilias Georgalas,2 Efstratios Parikakis,1 Panagiotis Mitropoulos1 1Second Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, Greece; 2First Department of Ophthalmology, University of Athens, Athens, Greece Purpose: To ev...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-11-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/location-of-submacular-hemorrhage-as-a-predictor-of-visual-outcome-aft-peer-reviewed-article-CIA |
| _version_ | 1819022600053981184 |
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| author | Karagiannis D Chatziralli I Kaprinis K Georgalas I Parikakis E Mitropoulos P |
| author_facet | Karagiannis D Chatziralli I Kaprinis K Georgalas I Parikakis E Mitropoulos P |
| author_sort | Karagiannis D |
| collection | DOAJ |
| description | Dimitrios Karagiannis,1 Irini Chatziralli,1 Konstantinos Kaprinis,1 Ilias Georgalas,2 Efstratios Parikakis,1 Panagiotis Mitropoulos1 1Second Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, Greece; 2First Department of Ophthalmology, University of Athens, Athens, Greece Purpose: To evaluate the anatomical and functional outcomes in patients with submacular hemorrhage (SMH) due to age-related macular degeneration (AMD) treated with ranibizumab, and to evaluate the potential role of the SMH location in the final outcome after treatment. Methods: Participants in this study were 12 treatment-naïve patients with SMH due to neovascular AMD who were treated with intravitreal ranibizumab and had at least 12 months’ follow-up. All patients underwent best-corrected visual acuity measurement and optical coherence tomography at baseline and at every visit posttreatment, while fluorescein angiography was done at baseline and at the discretion of the physician thereafter. Results: Of the patients, 83.4% showed improvement or stabilization in best-corrected visual acuity after treatment at the 12-month follow-up, with a mean number of 7.3±2.9 injections. Patients with SMH surrounding the foveal area in 360° presented worse anatomical and functional outcomes compared to those with SMH adjacent to the fovea. Conclusion: Intravitreal ranibizumab seems to be safe and effective, either improving or stabilizing visual acuity, in patients with SMH due to wet AMD. The location of the SMH may predict the final outcome after treatment. Keywords: age-related macular degeneration, ranibizumab, submacular hemorrhage, treatment |
| first_indexed | 2024-12-21T04:25:34Z |
| format | Article |
| id | doaj.art-95388962b20a4e7999776faddcf1b08b |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-21T04:25:34Z |
| publishDate | 2017-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-95388962b20a4e7999776faddcf1b08b2022-12-21T19:16:04ZengDove Medical PressClinical Interventions in Aging1178-19982017-11-01Volume 121829183335440Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degenerationKaragiannis DChatziralli IKaprinis KGeorgalas IParikakis EMitropoulos PDimitrios Karagiannis,1 Irini Chatziralli,1 Konstantinos Kaprinis,1 Ilias Georgalas,2 Efstratios Parikakis,1 Panagiotis Mitropoulos1 1Second Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, Greece; 2First Department of Ophthalmology, University of Athens, Athens, Greece Purpose: To evaluate the anatomical and functional outcomes in patients with submacular hemorrhage (SMH) due to age-related macular degeneration (AMD) treated with ranibizumab, and to evaluate the potential role of the SMH location in the final outcome after treatment. Methods: Participants in this study were 12 treatment-naïve patients with SMH due to neovascular AMD who were treated with intravitreal ranibizumab and had at least 12 months’ follow-up. All patients underwent best-corrected visual acuity measurement and optical coherence tomography at baseline and at every visit posttreatment, while fluorescein angiography was done at baseline and at the discretion of the physician thereafter. Results: Of the patients, 83.4% showed improvement or stabilization in best-corrected visual acuity after treatment at the 12-month follow-up, with a mean number of 7.3±2.9 injections. Patients with SMH surrounding the foveal area in 360° presented worse anatomical and functional outcomes compared to those with SMH adjacent to the fovea. Conclusion: Intravitreal ranibizumab seems to be safe and effective, either improving or stabilizing visual acuity, in patients with SMH due to wet AMD. The location of the SMH may predict the final outcome after treatment. Keywords: age-related macular degeneration, ranibizumab, submacular hemorrhage, treatmenthttps://www.dovepress.com/location-of-submacular-hemorrhage-as-a-predictor-of-visual-outcome-aft-peer-reviewed-article-CIAAge-related macular degenerationranibizumabsubmacular hemorrhagetreatment |
| spellingShingle | Karagiannis D Chatziralli I Kaprinis K Georgalas I Parikakis E Mitropoulos P Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration Clinical Interventions in Aging Age-related macular degeneration ranibizumab submacular hemorrhage treatment |
| title | Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration |
| title_full | Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration |
| title_fullStr | Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration |
| title_full_unstemmed | Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration |
| title_short | Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration |
| title_sort | location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age related macular degeneration |
| topic | Age-related macular degeneration ranibizumab submacular hemorrhage treatment |
| url | https://www.dovepress.com/location-of-submacular-hemorrhage-as-a-predictor-of-visual-outcome-aft-peer-reviewed-article-CIA |
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