Comparative Metabolomic Study of <i>Drosophila</i> Species with Different Lifespans
The increase in life expectancy, leading to a rise in the proportion of older people, is accompanied by a prevalence of age-related disorders among the world population, the fight against which today is one of the leading biomedical challenges. Exploring the biological insights concerning the lifesp...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/23/12873 |
| _version_ | 1797507721116778496 |
|---|---|
| author | Dmitry L. Maslov Nadezhda V. Zemskaya Oxana P. Trifonova Steven Lichtenberg Elena E. Balashova Andrey V. Lisitsa Alexey A. Moskalev Petr G. Lokhov |
| author_facet | Dmitry L. Maslov Nadezhda V. Zemskaya Oxana P. Trifonova Steven Lichtenberg Elena E. Balashova Andrey V. Lisitsa Alexey A. Moskalev Petr G. Lokhov |
| author_sort | Dmitry L. Maslov |
| collection | DOAJ |
| description | The increase in life expectancy, leading to a rise in the proportion of older people, is accompanied by a prevalence of age-related disorders among the world population, the fight against which today is one of the leading biomedical challenges. Exploring the biological insights concerning the lifespan is one of the ways to provide a background for designing an effective treatment for the increase in healthy years of life. Untargeted direct injection mass spectrometry-based metabolite profiling of 12 species of <i>Drosophila</i> with significant variations in natural lifespans was conducted in this research. A cross-comparison study of metabolomic profiles revealed lifespan signatures of flies. These signatures indicate that lifespan extension is associated with the upregulation of amino acids, phospholipids, and carbohydrate metabolism. Such information provides a metabolome-level view on longevity and may provide a molecular measure of organism age in age-related studies. |
| first_indexed | 2024-03-10T04:53:28Z |
| format | Article |
| id | doaj.art-95392acd53284dc9a6379daad6e09a08 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:53:28Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-95392acd53284dc9a6379daad6e09a082023-11-23T02:29:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122231287310.3390/ijms222312873Comparative Metabolomic Study of <i>Drosophila</i> Species with Different LifespansDmitry L. Maslov0Nadezhda V. Zemskaya1Oxana P. Trifonova2Steven Lichtenberg3Elena E. Balashova4Andrey V. Lisitsa5Alexey A. Moskalev6Petr G. Lokhov7Analytical Branch, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, RussiaLaboratory of Geroprotective and Radioprotective Technologies, Komi Science Center, Institute of Biology, Russian Academy of Sciences, 167982 Syktyvkar, RussiaAnalytical Branch, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, RussiaAnalytical Branch, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, RussiaAnalytical Branch, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, RussiaAnalytical Branch, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, RussiaLaboratory of Geroprotective and Radioprotective Technologies, Komi Science Center, Institute of Biology, Russian Academy of Sciences, 167982 Syktyvkar, RussiaAnalytical Branch, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, RussiaThe increase in life expectancy, leading to a rise in the proportion of older people, is accompanied by a prevalence of age-related disorders among the world population, the fight against which today is one of the leading biomedical challenges. Exploring the biological insights concerning the lifespan is one of the ways to provide a background for designing an effective treatment for the increase in healthy years of life. Untargeted direct injection mass spectrometry-based metabolite profiling of 12 species of <i>Drosophila</i> with significant variations in natural lifespans was conducted in this research. A cross-comparison study of metabolomic profiles revealed lifespan signatures of flies. These signatures indicate that lifespan extension is associated with the upregulation of amino acids, phospholipids, and carbohydrate metabolism. Such information provides a metabolome-level view on longevity and may provide a molecular measure of organism age in age-related studies.https://www.mdpi.com/1422-0067/22/23/12873metabolomicsmetabolome profilingdirect mass spectrometrylongevityagingfruit fly |
| spellingShingle | Dmitry L. Maslov Nadezhda V. Zemskaya Oxana P. Trifonova Steven Lichtenberg Elena E. Balashova Andrey V. Lisitsa Alexey A. Moskalev Petr G. Lokhov Comparative Metabolomic Study of <i>Drosophila</i> Species with Different Lifespans International Journal of Molecular Sciences metabolomics metabolome profiling direct mass spectrometry longevity aging fruit fly |
| title | Comparative Metabolomic Study of <i>Drosophila</i> Species with Different Lifespans |
| title_full | Comparative Metabolomic Study of <i>Drosophila</i> Species with Different Lifespans |
| title_fullStr | Comparative Metabolomic Study of <i>Drosophila</i> Species with Different Lifespans |
| title_full_unstemmed | Comparative Metabolomic Study of <i>Drosophila</i> Species with Different Lifespans |
| title_short | Comparative Metabolomic Study of <i>Drosophila</i> Species with Different Lifespans |
| title_sort | comparative metabolomic study of i drosophila i species with different lifespans |
| topic | metabolomics metabolome profiling direct mass spectrometry longevity aging fruit fly |
| url | https://www.mdpi.com/1422-0067/22/23/12873 |
| work_keys_str_mv | AT dmitrylmaslov comparativemetabolomicstudyofidrosophilaispecieswithdifferentlifespans AT nadezhdavzemskaya comparativemetabolomicstudyofidrosophilaispecieswithdifferentlifespans AT oxanaptrifonova comparativemetabolomicstudyofidrosophilaispecieswithdifferentlifespans AT stevenlichtenberg comparativemetabolomicstudyofidrosophilaispecieswithdifferentlifespans AT elenaebalashova comparativemetabolomicstudyofidrosophilaispecieswithdifferentlifespans AT andreyvlisitsa comparativemetabolomicstudyofidrosophilaispecieswithdifferentlifespans AT alexeyamoskalev comparativemetabolomicstudyofidrosophilaispecieswithdifferentlifespans AT petrglokhov comparativemetabolomicstudyofidrosophilaispecieswithdifferentlifespans |