Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights
This report explores the available curative molecules directed against hepatocellular carcinoma (HCC). Limited efficiency as well as other drawbacks of existing molecules led to the search for promising potential alternatives. Understanding of the cell signaling mechanisms propelling carcinogenesis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/19/10774 |
| _version_ | 1797516282511228928 |
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| author | Nouf Juaid Amr Amin Ali Abdalla Kevin Reese Zaenah Alamri Mohamed Moulay Suzan Abdu Nabil Miled |
| author_facet | Nouf Juaid Amr Amin Ali Abdalla Kevin Reese Zaenah Alamri Mohamed Moulay Suzan Abdu Nabil Miled |
| author_sort | Nouf Juaid |
| collection | DOAJ |
| description | This report explores the available curative molecules directed against hepatocellular carcinoma (HCC). Limited efficiency as well as other drawbacks of existing molecules led to the search for promising potential alternatives. Understanding of the cell signaling mechanisms propelling carcinogenesis and driven by cell proliferation, invasion, and angiogenesis can offer valuable information for the investigation of efficient treatment strategies. The complexity of the mechanisms behind carcinogenesis inspires researchers to explore the ability of various biomolecules to target specific pathways. Natural components occurring mainly in food and medicinal plants, are considered an essential resource for discovering new and promising therapeutic molecules. Novel biomolecules normally have an advantage in terms of biosafety. They are also widely diverse and often possess potent antioxidant, anti-inflammatory, and anti-cancer properties. Based on quantitative structure–activity relationship studies, biomolecules can be used as templates for chemical modifications that improve efficiency, safety, and bioavailability. In this review, we focus on anti-HCC biomolecules that have their molecular targets partially or completely characterized as well as having anti-cancer molecular mechanisms that are fairly described. |
| first_indexed | 2024-03-10T06:59:03Z |
| format | Article |
| id | doaj.art-95395092c3f34805b34a282b957de27e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:59:03Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-95395092c3f34805b34a282b957de27e2023-11-22T16:15:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122191077410.3390/ijms221910774Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets InsightsNouf Juaid0Amr Amin1Ali Abdalla2Kevin Reese3Zaenah Alamri4Mohamed Moulay5Suzan Abdu6Nabil Miled7Department of Biological Sciences, University of Jeddah, Jeddah 23445, Saudi ArabiaBiology Department, UAE University, Al Ain 15551, United Arab EmiratesWeinberg Institute for Cognitive Science, University of Michigan, Ann Arbor, MI 48109, USADepartment of Kinesiology, Michigan State University, East Lansing, MI 48824, USADepartment of Biological Sciences, University of Jeddah, Jeddah 23445, Saudi ArabiaEmbryonic Stem Cell Research Unit, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah 22252, Saudi ArabiaDepartment of Biological Sciences, University of Jeddah, Jeddah 23445, Saudi ArabiaDepartment of Biological Sciences, University of Jeddah, Jeddah 23445, Saudi ArabiaThis report explores the available curative molecules directed against hepatocellular carcinoma (HCC). Limited efficiency as well as other drawbacks of existing molecules led to the search for promising potential alternatives. Understanding of the cell signaling mechanisms propelling carcinogenesis and driven by cell proliferation, invasion, and angiogenesis can offer valuable information for the investigation of efficient treatment strategies. The complexity of the mechanisms behind carcinogenesis inspires researchers to explore the ability of various biomolecules to target specific pathways. Natural components occurring mainly in food and medicinal plants, are considered an essential resource for discovering new and promising therapeutic molecules. Novel biomolecules normally have an advantage in terms of biosafety. They are also widely diverse and often possess potent antioxidant, anti-inflammatory, and anti-cancer properties. Based on quantitative structure–activity relationship studies, biomolecules can be used as templates for chemical modifications that improve efficiency, safety, and bioavailability. In this review, we focus on anti-HCC biomolecules that have their molecular targets partially or completely characterized as well as having anti-cancer molecular mechanisms that are fairly described.https://www.mdpi.com/1422-0067/22/19/10774hepatocellular carcinomacancerdrugmolecular targetsignaling pathwayphytochemicals |
| spellingShingle | Nouf Juaid Amr Amin Ali Abdalla Kevin Reese Zaenah Alamri Mohamed Moulay Suzan Abdu Nabil Miled Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights International Journal of Molecular Sciences hepatocellular carcinoma cancer drug molecular target signaling pathway phytochemicals |
| title | Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights |
| title_full | Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights |
| title_fullStr | Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights |
| title_full_unstemmed | Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights |
| title_short | Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights |
| title_sort | anti hepatocellular carcinoma biomolecules molecular targets insights |
| topic | hepatocellular carcinoma cancer drug molecular target signaling pathway phytochemicals |
| url | https://www.mdpi.com/1422-0067/22/19/10774 |
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