An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma

An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma

Abstract Medulloblastoma (MB) is a pediatric tumor of the cerebellum divided into four groups. Group 3 is of bad prognosis and remains poorly characterized. While the current treatment involving surgery, radiotherapy, and chemotherapy often fails, no alternative therapy is yet available. Few recurre...

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Bibliographic Details
Main Authors: Morgane Morabito, Magalie Larcher, Florence MG Cavalli, Chloé Foray, Antoine Forget, Liliana Mirabal‐Ortega, Mamy Andrianteranagna, Sabine Druillennec, Alexandra Garancher, Julien Masliah‐Planchon, Sophie Leboucher, Abel Debalkew, Alessandro Raso, Olivier Delattre, Stéphanie Puget, François Doz, Michael D Taylor, Olivier Ayrault, Franck Bourdeaut, Alain Eychène, Celio Pouponnot
Format: Article
Language:English
Published: Springer Nature 2019-08-01
Series:EMBO Molecular Medicine
Subjects:
activin
medulloblastoma
Smad2
Smad3
TGFbeta
Online Access:https://doi.org/10.15252/emmm.201809830

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