Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3.

Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3.

Alterations in the ubiquitin-proteasome system (UPS) have been reported in several neurodegenerative disorders characterized by protein misfolding and aggregation, including the polylgutamine diseases. Machado-Joseph disease (MJD) or Spinocerebellar Ataxia type 3 is caused by a polyglutamine-encodin...

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Bibliographic Details
Main Authors: Mário N Laço, Luisa Cortes, Sue M Travis, Henry L Paulson, A Cristina Rego
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3435318?pdf=render

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