Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear
The periodic organization of cells is typically associated with mechanisms based on intercellular signaling such as lateral inhibition and Turing patterning. Here the authors show that hair cells in the inner ear rearrange gradually into a checkerboard-like pattern through a tissue-wide shear motion...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18894-8 |
| _version_ | 1818892449181859840 |
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| author | Roie Cohen Liat Amir-Zilberstein Micha Hersch Shiran Woland Olga Loza Shahar Taiber Fumio Matsuzaki Sven Bergmann Karen B. Avraham David Sprinzak |
| author_facet | Roie Cohen Liat Amir-Zilberstein Micha Hersch Shiran Woland Olga Loza Shahar Taiber Fumio Matsuzaki Sven Bergmann Karen B. Avraham David Sprinzak |
| author_sort | Roie Cohen |
| collection | DOAJ |
| description | The periodic organization of cells is typically associated with mechanisms based on intercellular signaling such as lateral inhibition and Turing patterning. Here the authors show that hair cells in the inner ear rearrange gradually into a checkerboard-like pattern through a tissue-wide shear motion that coordinates intercalation and delamination events. |
| first_indexed | 2024-12-19T17:56:53Z |
| format | Article |
| id | doaj.art-953a8cdf5ac942b88ac0bd29afb3bdd8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T17:56:53Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-953a8cdf5ac942b88ac0bd29afb3bdd82022-12-21T20:11:47ZengNature PortfolioNature Communications2041-17232020-10-0111111210.1038/s41467-020-18894-8Mechanical forces drive ordered patterning of hair cells in the mammalian inner earRoie Cohen0Liat Amir-Zilberstein1Micha Hersch2Shiran Woland3Olga Loza4Shahar Taiber5Fumio Matsuzaki6Sven Bergmann7Karen B. Avraham8David Sprinzak9George S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv UniversityGeorge S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv UniversityDepartment of Computational Biology, University of LausanneGeorge S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv UniversityGeorge S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv UniversityGeorge S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv UniversityLaboratory of Cell Asymmetry, RIKEN Center for Biosystems Dynamics ResearchDepartment of Computational Biology, University of LausanneSackler Faculty of Medicine and Sagol School of Neuroscience, Department of Human Molecular Genetics and Biochemistry, Tel Aviv UniversityGeorge S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv UniversityThe periodic organization of cells is typically associated with mechanisms based on intercellular signaling such as lateral inhibition and Turing patterning. Here the authors show that hair cells in the inner ear rearrange gradually into a checkerboard-like pattern through a tissue-wide shear motion that coordinates intercalation and delamination events.https://doi.org/10.1038/s41467-020-18894-8 |
| spellingShingle | Roie Cohen Liat Amir-Zilberstein Micha Hersch Shiran Woland Olga Loza Shahar Taiber Fumio Matsuzaki Sven Bergmann Karen B. Avraham David Sprinzak Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear Nature Communications |
| title | Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear |
| title_full | Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear |
| title_fullStr | Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear |
| title_full_unstemmed | Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear |
| title_short | Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear |
| title_sort | mechanical forces drive ordered patterning of hair cells in the mammalian inner ear |
| url | https://doi.org/10.1038/s41467-020-18894-8 |
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