Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis
Previous researches have emphasized a trypsin-centered theory of acute pancreatitis (AP) for more than a century. With additional studies into the pathogenesis of AP, new mechanisms have been explored. Among them, the role of immune response bears great importance. Pro-inflammatory substances, espec...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.927193/full |
| _version_ | 1811216532020133888 |
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| author | Xiaoying Zhou Xiaoying Zhou Shengchun Jin Jingyi Pan Qingyi Lin Shaopeng Yang Peter C. Ambe Zarrin Basharat Vincent Zimmer Vincent Zimmer Wei Wang Wei Wang Wandong Hong |
| author_facet | Xiaoying Zhou Xiaoying Zhou Shengchun Jin Jingyi Pan Qingyi Lin Shaopeng Yang Peter C. Ambe Zarrin Basharat Vincent Zimmer Vincent Zimmer Wei Wang Wei Wang Wandong Hong |
| author_sort | Xiaoying Zhou |
| collection | DOAJ |
| description | Previous researches have emphasized a trypsin-centered theory of acute pancreatitis (AP) for more than a century. With additional studies into the pathogenesis of AP, new mechanisms have been explored. Among them, the role of immune response bears great importance. Pro-inflammatory substances, especially damage-associated molecular patterns (DAMPs), play an essential role in activating, signaling, and steering inflammation. Meanwhile, activated neutrophils attach great importance to the immune defense by forming neutrophil extracellular traps (NETs), which cause ductal obstruction, premature trypsinogen activation, and modulate inflammation. In this review, we discuss the latest advances in understanding the pathological role of DAMPs and NETs in AP and shed light on the flexible crosstalk between these vital inflammatory mediators. We, then highlight the potentially promising treatment for AP targeting DAMPs and NETs, with a focus on novel insights into the mechanism, diagnosis, and management of AP. |
| first_indexed | 2024-04-12T06:40:43Z |
| format | Article |
| id | doaj.art-953b607910aa4176acacaf73388000f4 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-12T06:40:43Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-953b607910aa4176acacaf73388000f42022-12-22T03:43:45ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-08-011210.3389/fcimb.2022.927193927193Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitisXiaoying Zhou0Xiaoying Zhou1Shengchun Jin2Jingyi Pan3Qingyi Lin4Shaopeng Yang5Peter C. Ambe6Zarrin Basharat7Vincent Zimmer8Vincent Zimmer9Wei Wang10Wei Wang11Wandong Hong12Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of General Surgery, Visceral Surgery and Coloproctology, Vinzenz-Pallotti-Hospital Bensberg, Bensberg, GermanyJamil-ur-Rahman Center for Genome Research, Dr. Panjwani Centre for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, PakistanDepartment of Medicine, Marienhausklinik St. Josef Kohlhof, Neunkirchen, GermanyDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, GermanySchool of Mental Health, Wenzhou Medical University, Wenzhou, ChinaZhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaPrevious researches have emphasized a trypsin-centered theory of acute pancreatitis (AP) for more than a century. With additional studies into the pathogenesis of AP, new mechanisms have been explored. Among them, the role of immune response bears great importance. Pro-inflammatory substances, especially damage-associated molecular patterns (DAMPs), play an essential role in activating, signaling, and steering inflammation. Meanwhile, activated neutrophils attach great importance to the immune defense by forming neutrophil extracellular traps (NETs), which cause ductal obstruction, premature trypsinogen activation, and modulate inflammation. In this review, we discuss the latest advances in understanding the pathological role of DAMPs and NETs in AP and shed light on the flexible crosstalk between these vital inflammatory mediators. We, then highlight the potentially promising treatment for AP targeting DAMPs and NETs, with a focus on novel insights into the mechanism, diagnosis, and management of AP.https://www.frontiersin.org/articles/10.3389/fcimb.2022.927193/fullDAMPs (damage-associated molecular patterns)NETs (neutrophil extracellular traps)acute pancreatitis (AP)HMGB1 (high mobility group box 1)HSP (heat shock protein)histone |
| spellingShingle | Xiaoying Zhou Xiaoying Zhou Shengchun Jin Jingyi Pan Qingyi Lin Shaopeng Yang Peter C. Ambe Zarrin Basharat Vincent Zimmer Vincent Zimmer Wei Wang Wei Wang Wandong Hong Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis Frontiers in Cellular and Infection Microbiology DAMPs (damage-associated molecular patterns) NETs (neutrophil extracellular traps) acute pancreatitis (AP) HMGB1 (high mobility group box 1) HSP (heat shock protein) histone |
| title | Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis |
| title_full | Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis |
| title_fullStr | Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis |
| title_full_unstemmed | Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis |
| title_short | Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis |
| title_sort | damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis |
| topic | DAMPs (damage-associated molecular patterns) NETs (neutrophil extracellular traps) acute pancreatitis (AP) HMGB1 (high mobility group box 1) HSP (heat shock protein) histone |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.927193/full |
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