Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy
Immunotherapy with checkpoint inhibitors (ICIs) is becoming standard of practice for an increasing number of cancer types. ICIs enhance T-cell action against the cancer cells. By unbalancing the immune system ICIs may cause dysimmune toxicities, a series of disorders broadly defined immune-related a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/10/4/216 |
| _version_ | 1827718810114719744 |
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| author | Vanina Vani Daniele Regge Giovanni Cappello Michela Gabelloni Emanuele Neri |
| author_facet | Vanina Vani Daniele Regge Giovanni Cappello Michela Gabelloni Emanuele Neri |
| author_sort | Vanina Vani |
| collection | DOAJ |
| description | Immunotherapy with checkpoint inhibitors (ICIs) is becoming standard of practice for an increasing number of cancer types. ICIs enhance T-cell action against the cancer cells. By unbalancing the immune system ICIs may cause dysimmune toxicities, a series of disorders broadly defined immune-related adverse events (irAEs). IrAEs may affect any organ or apparatus and most frequently involve skin, colon, endocrine organs, liver, and lungs. Early identification and appropriate treatment of irAEs can improve patient outcome. The paper aims at reviewing mechanisms of the occurrence of irAEs, the importance of a proper diagnosis and the main pillars of therapy. To provide effective guidance to the comprehension of major irAEs imaging findings will be reviewed. |
| first_indexed | 2024-03-10T20:31:10Z |
| format | Article |
| id | doaj.art-953be26b658447f08168464313727132 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T20:31:10Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-953be26b658447f081684643137271322023-11-19T21:26:30ZengMDPI AGDiagnostics2075-44182020-04-0110421610.3390/diagnostics10040216Imaging of Adverse Events Related to Checkpoint Inhibitor TherapyVanina Vani0Daniele Regge1Giovanni Cappello2Michela Gabelloni3Emanuele Neri4Department of Translational Research, University of Pisa, Via Roma 67, 56126 Pisa, ItalyRadiology Unit, Candiolo Cancer Institute, FPO-IRCCS, University of Torino, Candiolo, 10060 Turin, ItalyCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Turin, ItalyDepartment of Translational Research, University of Pisa, Via Roma 67, 56126 Pisa, ItalyDepartment of Translational Research, University of Pisa, Via Roma 67, 56126 Pisa, ItalyImmunotherapy with checkpoint inhibitors (ICIs) is becoming standard of practice for an increasing number of cancer types. ICIs enhance T-cell action against the cancer cells. By unbalancing the immune system ICIs may cause dysimmune toxicities, a series of disorders broadly defined immune-related adverse events (irAEs). IrAEs may affect any organ or apparatus and most frequently involve skin, colon, endocrine organs, liver, and lungs. Early identification and appropriate treatment of irAEs can improve patient outcome. The paper aims at reviewing mechanisms of the occurrence of irAEs, the importance of a proper diagnosis and the main pillars of therapy. To provide effective guidance to the comprehension of major irAEs imaging findings will be reviewed.https://www.mdpi.com/2075-4418/10/4/216immune checkpoint inhibitorstherapytoxicityoncologic imaging |
| spellingShingle | Vanina Vani Daniele Regge Giovanni Cappello Michela Gabelloni Emanuele Neri Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy Diagnostics immune checkpoint inhibitors therapy toxicity oncologic imaging |
| title | Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy |
| title_full | Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy |
| title_fullStr | Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy |
| title_full_unstemmed | Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy |
| title_short | Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy |
| title_sort | imaging of adverse events related to checkpoint inhibitor therapy |
| topic | immune checkpoint inhibitors therapy toxicity oncologic imaging |
| url | https://www.mdpi.com/2075-4418/10/4/216 |
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