Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers
The bromodomain and extraterminal (BET) domain protein family is involved in the process of transcription of genetic information. The BET protein family includes BRD2, BRD3, BRD4, and bromodomain testis-specific protein. BET protein alterations are associated with some solid tumor cancers, including...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Innovative Healthcare Institute
2020-02-01
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| Series: | Journal of Immunotherapy and Precision Oncology |
| Subjects: | |
| Online Access: | https://jipo.org/doi/pdf/10.4103/JIPO.JIPO_2_20 |
| _version_ | 1797962735717187584 |
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| author | Martin V. Nguyen Lydia Loof Gerald S. Falchook |
| author_facet | Martin V. Nguyen Lydia Loof Gerald S. Falchook |
| author_sort | Martin V. Nguyen |
| collection | DOAJ |
| description | The bromodomain and extraterminal (BET) domain protein family is involved in the process of transcription of genetic information. The BET protein family includes BRD2, BRD3, BRD4, and bromodomain testis-specific protein. BET protein alterations are associated with some solid tumor cancers, including nuclear protein in testis midline carcinoma. BET protein has a role in carcinogenesis and in the regulation of the cell cycle. A number of BET inhibitors have entered clinical trials. This review discusses the results of BET inhibitor clinical trials in solid tumor cancers. |
| first_indexed | 2024-04-11T01:17:34Z |
| format | Article |
| id | doaj.art-953c704e02074f5595cc1efcdade115b |
| institution | Directory Open Access Journal |
| issn | 2666-2345 2590-017X |
| language | English |
| last_indexed | 2024-04-11T01:17:34Z |
| publishDate | 2020-02-01 |
| publisher | Innovative Healthcare Institute |
| record_format | Article |
| series | Journal of Immunotherapy and Precision Oncology |
| spelling | doaj.art-953c704e02074f5595cc1efcdade115b2023-01-03T19:58:36ZengInnovative Healthcare InstituteJournal of Immunotherapy and Precision Oncology2666-23452590-017X2020-02-01162210.4103/JIPO.JIPO_2_20i2590-017X-3-1-review_article_2Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor CancersMartin V. Nguyen0Lydia Loof1Gerald S. Falchook21 Sarah Cannon Research Institute at HealthONE, Denver, CO, USA1 Sarah Cannon Research Institute at HealthONE, Denver, CO, USA1 Sarah Cannon Research Institute at HealthONE, Denver, CO, USAThe bromodomain and extraterminal (BET) domain protein family is involved in the process of transcription of genetic information. The BET protein family includes BRD2, BRD3, BRD4, and bromodomain testis-specific protein. BET protein alterations are associated with some solid tumor cancers, including nuclear protein in testis midline carcinoma. BET protein has a role in carcinogenesis and in the regulation of the cell cycle. A number of BET inhibitors have entered clinical trials. This review discusses the results of BET inhibitor clinical trials in solid tumor cancers.https://jipo.org/doi/pdf/10.4103/JIPO.JIPO_2_20bromodomain and extraterminal domainbromodomain and extraterminal inhibitorcancerclinical trialreview |
| spellingShingle | Martin V. Nguyen Lydia Loof Gerald S. Falchook Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers Journal of Immunotherapy and Precision Oncology bromodomain and extraterminal domain bromodomain and extraterminal inhibitor cancer clinical trial review |
| title | Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers |
| title_full | Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers |
| title_fullStr | Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers |
| title_full_unstemmed | Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers |
| title_short | Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers |
| title_sort | bromodomain and extra terminal bet domain protein inhibitors for solid tumor cancers |
| topic | bromodomain and extraterminal domain bromodomain and extraterminal inhibitor cancer clinical trial review |
| url | https://jipo.org/doi/pdf/10.4103/JIPO.JIPO_2_20 |
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