Hepatitis C Virus among Iraqi Patients on Renal Dialysis, Some Immunological Profiles
Back ground: Chronic hepatitis C (HCV) is the most common chronic liver disease at present, and HCV infection is found with variable prevalence in dialysis populations in different parts of the world. Objective: The aim of this study was to determine the concentration of sialic acid and immunoglobul...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2012-10-01
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| Series: | مجلة كلية الطب |
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| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/731 |
| _version_ | 1797333026734080000 |
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| author | Anwar I. S. Al-Assaf |
| author_facet | Anwar I. S. Al-Assaf |
| author_sort | Anwar I. S. Al-Assaf |
| collection | DOAJ |
| description | Back ground: Chronic hepatitis C (HCV) is the most common chronic liver disease at present, and HCV infection is found with variable prevalence in dialysis populations in different parts of the world.
Objective: The aim of this study was to determine the concentration of sialic acid and immunoglobulins level in the sera of patients with chronic renal failure whom infected with Hepatitis C virus, and the effect of hemodialysis on them.
Patients&Methods: Regarding to this aim, total sialic acid levels (TSA) and immunoglobulins level were studied on the blood samples of 20 patients with chronic renal failure + Hepatitis C virus (positive group) and 20 patients with chronic renal failure (negative group) and 20 healthy volunteers. Serum TSA determinations were carried out by the resorcinol method.
Results: In (positive group), the mean of TSA concentration (after hemodialysis treatment) was 68 ± 2.9 mg/dl, and the mean of TSA concentration in (negative group) was 110.7 ±7.5 mg/dl, while the mean TSA level in healthy control group was 58.3 ± 1.7 mg/dl. Also, this study aimed to assess serum concentration of immunoglobulins: IgG, IgM and IgA. Serum IgG was increased in patients of (positive group) and (negative group) with respect to control healthy (6.1, 5.5, 5.4 respectively) (p<0.05).There was no significant difference between the third groups in serum IgM concentration (6.6, 6, 6.2 respectively).Also in serum IgA concentration (5.8, 6, 5.5 respectively).
Conclusion: We conclude that the TSA levels in the first groups both were found to be significantly elevated as compared to control levels (p<0.05), and Hepatitis C virus are linked to selective increase of serum IgG. |
| first_indexed | 2024-03-08T07:57:54Z |
| format | Article |
| id | doaj.art-953c7dc71ece48dca0fe1ddf85712f4e |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T07:57:54Z |
| publishDate | 2012-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-953c7dc71ece48dca0fe1ddf85712f4e2024-02-02T13:11:19ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572012-10-0154310.32007/jfacmedbagdad.v3243-246%Hepatitis C Virus among Iraqi Patients on Renal Dialysis, Some Immunological ProfilesAnwar I. S. Al-Assaf0Department of Biology, College of Education Ibn Al-Haitham, University of Baghdad.Back ground: Chronic hepatitis C (HCV) is the most common chronic liver disease at present, and HCV infection is found with variable prevalence in dialysis populations in different parts of the world. Objective: The aim of this study was to determine the concentration of sialic acid and immunoglobulins level in the sera of patients with chronic renal failure whom infected with Hepatitis C virus, and the effect of hemodialysis on them. Patients&Methods: Regarding to this aim, total sialic acid levels (TSA) and immunoglobulins level were studied on the blood samples of 20 patients with chronic renal failure + Hepatitis C virus (positive group) and 20 patients with chronic renal failure (negative group) and 20 healthy volunteers. Serum TSA determinations were carried out by the resorcinol method. Results: In (positive group), the mean of TSA concentration (after hemodialysis treatment) was 68 ± 2.9 mg/dl, and the mean of TSA concentration in (negative group) was 110.7 ±7.5 mg/dl, while the mean TSA level in healthy control group was 58.3 ± 1.7 mg/dl. Also, this study aimed to assess serum concentration of immunoglobulins: IgG, IgM and IgA. Serum IgG was increased in patients of (positive group) and (negative group) with respect to control healthy (6.1, 5.5, 5.4 respectively) (p<0.05).There was no significant difference between the third groups in serum IgM concentration (6.6, 6, 6.2 respectively).Also in serum IgA concentration (5.8, 6, 5.5 respectively). Conclusion: We conclude that the TSA levels in the first groups both were found to be significantly elevated as compared to control levels (p<0.05), and Hepatitis C virus are linked to selective increase of serum IgG.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/731Hepatitis C virus, Hemodialysis, Sialic acid, Immunoglobulins. |
| spellingShingle | Anwar I. S. Al-Assaf Hepatitis C Virus among Iraqi Patients on Renal Dialysis, Some Immunological Profiles مجلة كلية الطب Hepatitis C virus, Hemodialysis, Sialic acid, Immunoglobulins. |
| title | Hepatitis C Virus among Iraqi Patients on Renal Dialysis, Some Immunological Profiles |
| title_full | Hepatitis C Virus among Iraqi Patients on Renal Dialysis, Some Immunological Profiles |
| title_fullStr | Hepatitis C Virus among Iraqi Patients on Renal Dialysis, Some Immunological Profiles |
| title_full_unstemmed | Hepatitis C Virus among Iraqi Patients on Renal Dialysis, Some Immunological Profiles |
| title_short | Hepatitis C Virus among Iraqi Patients on Renal Dialysis, Some Immunological Profiles |
| title_sort | hepatitis c virus among iraqi patients on renal dialysis some immunological profiles |
| topic | Hepatitis C virus, Hemodialysis, Sialic acid, Immunoglobulins. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/731 |
| work_keys_str_mv | AT anwarisalassaf hepatitiscvirusamongiraqipatientsonrenaldialysissomeimmunologicalprofiles |