A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosis
Objective: Hyperhidrosis can cause dehydration and exercise intolerance. There are several case reports of extremely high sweat rates in athletes. We present as case report of a 17-year-old male with the highest sweat rate recorded in the literature (5.8 L/h). Our goal was to determine if glycopyrro...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-08-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X17721601 |
| _version_ | 1811330658220376064 |
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| author | Matthew Negaard Christopher Anthony Daniel Bonthius Matthew Jepson Britt Marcussen Daniel Pelzer Andrew Peterson |
| author_facet | Matthew Negaard Christopher Anthony Daniel Bonthius Matthew Jepson Britt Marcussen Daniel Pelzer Andrew Peterson |
| author_sort | Matthew Negaard |
| collection | DOAJ |
| description | Objective: Hyperhidrosis can cause dehydration and exercise intolerance. There are several case reports of extremely high sweat rates in athletes. We present as case report of a 17-year-old male with the highest sweat rate recorded in the literature (5.8 L/h). Our goal was to determine if glycopyrrolate, an anticholinergic medication with primarily anti-muscarinic effects that is known to decrease sweat production, would reduce the sweat rate of our subject in a controlled exercise setting. Methods: Our patient and a control subject were subjected to an exercise protocol consisting of running on a treadmill (5.4–6.7 mile/h at 1° of incline) in a warm climate-controlled chamber after receiving 0, 2, or 4 mg of glycopyrrolate. Core temperature, heart rate, rater of perceived exertion, and sweat rate were monitored in both subjects. Results: Glycopyrrolate dose was not significantly correlated with decreased sweat rate and maximal core temperature. However, the clinical effect of reducing the sweat rate was very strong. The improvement of the subject’s sweat rate allowed him to successfully return to sport. Conclusion: Our findings suggest that low-dose glycopyrrolate may be a safe and effective method of controlling exertional hyperhidrosis. |
| first_indexed | 2024-04-13T16:06:58Z |
| format | Article |
| id | doaj.art-953cb200c74842b19b4c76a3f3917ba8 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-04-13T16:06:58Z |
| publishDate | 2017-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-953cb200c74842b19b4c76a3f3917ba82022-12-22T02:40:22ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2017-08-01510.1177/2050313X17721601A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosisMatthew Negaard0Christopher Anthony1Daniel Bonthius2Matthew Jepson3Britt Marcussen4Daniel Pelzer5Andrew Peterson6Department of Emergency Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USADepartment of Orthopedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USACollege of Medicine, Medical University of South Carolina, Charleston, SC, USADepartment of Family Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USADepartment of Family Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USADepartment of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USASports Medicine Clinic, University of Iowa Hospitals and Clinics, Iowa City, IA, USAObjective: Hyperhidrosis can cause dehydration and exercise intolerance. There are several case reports of extremely high sweat rates in athletes. We present as case report of a 17-year-old male with the highest sweat rate recorded in the literature (5.8 L/h). Our goal was to determine if glycopyrrolate, an anticholinergic medication with primarily anti-muscarinic effects that is known to decrease sweat production, would reduce the sweat rate of our subject in a controlled exercise setting. Methods: Our patient and a control subject were subjected to an exercise protocol consisting of running on a treadmill (5.4–6.7 mile/h at 1° of incline) in a warm climate-controlled chamber after receiving 0, 2, or 4 mg of glycopyrrolate. Core temperature, heart rate, rater of perceived exertion, and sweat rate were monitored in both subjects. Results: Glycopyrrolate dose was not significantly correlated with decreased sweat rate and maximal core temperature. However, the clinical effect of reducing the sweat rate was very strong. The improvement of the subject’s sweat rate allowed him to successfully return to sport. Conclusion: Our findings suggest that low-dose glycopyrrolate may be a safe and effective method of controlling exertional hyperhidrosis.https://doi.org/10.1177/2050313X17721601 |
| spellingShingle | Matthew Negaard Christopher Anthony Daniel Bonthius Matthew Jepson Britt Marcussen Daniel Pelzer Andrew Peterson A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosis SAGE Open Medical Case Reports |
| title | A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosis |
| title_full | A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosis |
| title_fullStr | A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosis |
| title_full_unstemmed | A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosis |
| title_short | A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosis |
| title_sort | case report glycopyrrolate for treatment of exercise induced hyperhidrosis |
| url | https://doi.org/10.1177/2050313X17721601 |
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