Prevalence of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes and its Correlation with Coronary Risk Factors
Introduction: Non-alcoholic fatty liver disease (NAFLD) is increasingly seen to be associated with metabolic syndrome and is considered a risk factor for coronary artery disease (CAD). Aim: To assess the prevalence of NAFLD among type 2 diabetics and assess correlation between risk factors of C...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Pvt. Ltd.
2016-10-01
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| Series: | National Journal of Laboratory Medicine |
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| Online Access: | http://www.njlm.net/articles/PDF/2168/20612_F(GH)_PF1(P_VSU)_PFA(GH)_PF2(VsuGH).pdf |
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| author | Raminderpal Singh Sibia Sandeep Dhoot Preetkanwal Sibia Sourabh Murarka Harnoor Bhardwaj Akash Deep Aggarwal |
| author_facet | Raminderpal Singh Sibia Sandeep Dhoot Preetkanwal Sibia Sourabh Murarka Harnoor Bhardwaj Akash Deep Aggarwal |
| author_sort | Raminderpal Singh Sibia |
| collection | DOAJ |
| description | Introduction: Non-alcoholic fatty liver disease (NAFLD) is
increasingly seen to be associated with metabolic syndrome
and is considered a risk factor for coronary artery disease
(CAD).
Aim: To assess the prevalence of NAFLD among type 2
diabetics and assess correlation between risk factors of CAD
and NAFLD in these patients.
Materials and Methods: This cross-sectional study was
conducted among 100 consecutive patients of type 2
diabetes coming to our institution. A detailed history, physical
examination and laboratory investigations including fasting
plasma glucose (FPG), renal and liver function tests, lipid
profile, glycated haemoglobin and ultrasound abdomen were
carried out. NAFLD was diagnosed on the basis of ultrasonic
assessment of the liver. The study group was then divided
into NAFLD and non-NAFLD group and the two groups were
compared for presence of risk factors for CAD.
Results: The prevalence of NAFLD in diabetics was 61% and
CAD was found to be more prevalent in this group. Also, the
NAFLD subgroup had higher prevalence of hypertension,
microalbuminuria, Metabolic syndrome and raised total
cholesterol, Low Density Lipoproteins (LDL) and triglycerides.
Conclusion: NAFLD as a disease is fairly prevalent among
type-2 diabetics and both these diseases occur simultaneously
in patients with other known coronary risk factors. Hence, the
presence of NAFLD can be considered as an important marker
of coronary artery disease amongst type 2 diabetics. It is noninvasive, economical, easily assessable and reproducible
parameter for coronary risk stratification in type 2 diabetics. |
| first_indexed | 2024-12-18T06:18:25Z |
| format | Article |
| id | doaj.art-953ce10246f7419cb23df931285bb819 |
| institution | Directory Open Access Journal |
| issn | 2277-8551 2455-6882 |
| language | English |
| last_indexed | 2024-12-18T06:18:25Z |
| publishDate | 2016-10-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | National Journal of Laboratory Medicine |
| spelling | doaj.art-953ce10246f7419cb23df931285bb8192022-12-21T21:18:12ZengJCDR Research and Publications Pvt. Ltd.National Journal of Laboratory Medicine2277-85512455-68822016-10-0154IO11IO1310.7860/NJLM/2016/20612:2168Prevalence of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes and its Correlation with Coronary Risk FactorsRaminderpal Singh Sibia0Sandeep Dhoot1Preetkanwal Sibia2Sourabh Murarka3Harnoor Bhardwaj4Akash Deep Aggarwal5Associate Professor, Department of Medicine, Govt. Medical College, Patiala, Punjab, India.Junior Resident, Department of Medicine, Govt. Medical College, Patiala, Punjab, India.Associate Professor, Department of Obstetrics and Gynaecology, Govt. Medical College, Patiala, Punjab, India.Junior Resident, Department of Medicine, Govt. Medical College, Patiala, Punjab, India.House Physician, Department of Medicine, Govt. Medical College, Patiala, Punjab, India.Associate Professor, Department of Forensic Medicine, Govt. Medical College, Patiala, Punjab, India.Introduction: Non-alcoholic fatty liver disease (NAFLD) is increasingly seen to be associated with metabolic syndrome and is considered a risk factor for coronary artery disease (CAD). Aim: To assess the prevalence of NAFLD among type 2 diabetics and assess correlation between risk factors of CAD and NAFLD in these patients. Materials and Methods: This cross-sectional study was conducted among 100 consecutive patients of type 2 diabetes coming to our institution. A detailed history, physical examination and laboratory investigations including fasting plasma glucose (FPG), renal and liver function tests, lipid profile, glycated haemoglobin and ultrasound abdomen were carried out. NAFLD was diagnosed on the basis of ultrasonic assessment of the liver. The study group was then divided into NAFLD and non-NAFLD group and the two groups were compared for presence of risk factors for CAD. Results: The prevalence of NAFLD in diabetics was 61% and CAD was found to be more prevalent in this group. Also, the NAFLD subgroup had higher prevalence of hypertension, microalbuminuria, Metabolic syndrome and raised total cholesterol, Low Density Lipoproteins (LDL) and triglycerides. Conclusion: NAFLD as a disease is fairly prevalent among type-2 diabetics and both these diseases occur simultaneously in patients with other known coronary risk factors. Hence, the presence of NAFLD can be considered as an important marker of coronary artery disease amongst type 2 diabetics. It is noninvasive, economical, easily assessable and reproducible parameter for coronary risk stratification in type 2 diabetics.http://www.njlm.net/articles/PDF/2168/20612_F(GH)_PF1(P_VSU)_PFA(GH)_PF2(VsuGH).pdfcholesterolhearthypertension |
| spellingShingle | Raminderpal Singh Sibia Sandeep Dhoot Preetkanwal Sibia Sourabh Murarka Harnoor Bhardwaj Akash Deep Aggarwal Prevalence of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes and its Correlation with Coronary Risk Factors National Journal of Laboratory Medicine cholesterol heart hypertension |
| title | Prevalence of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes and its Correlation with Coronary Risk Factors |
| title_full | Prevalence of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes and its Correlation with Coronary Risk Factors |
| title_fullStr | Prevalence of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes and its Correlation with Coronary Risk Factors |
| title_full_unstemmed | Prevalence of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes and its Correlation with Coronary Risk Factors |
| title_short | Prevalence of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes and its Correlation with Coronary Risk Factors |
| title_sort | prevalence of non alcoholic fatty liver disease in patients with type 2 diabetes and its correlation with coronary risk factors |
| topic | cholesterol heart hypertension |
| url | http://www.njlm.net/articles/PDF/2168/20612_F(GH)_PF1(P_VSU)_PFA(GH)_PF2(VsuGH).pdf |
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