Adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in PCOS women undergoing IVF/ICSI cycles
Abstract Background Polycystic ovary syndrome (PCOS) women have high incidences of dyslipidemia, obesity, impaired glucose tolerance (IGT), diabetes, and insulin resistance (IR) and are fragile to female infertility. Obesity and dyslipidemia may be the intermediate biological mechanism for the assoc...
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01174-8 |
| _version_ | 1797784708838326272 |
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| author | Huahua Jiang Manfei Si Tian Tian Huifeng Shi Ning Huang Hongbin Chi Rui Yang Xiaoyu Long Jie Qiao |
| author_facet | Huahua Jiang Manfei Si Tian Tian Huifeng Shi Ning Huang Hongbin Chi Rui Yang Xiaoyu Long Jie Qiao |
| author_sort | Huahua Jiang |
| collection | DOAJ |
| description | Abstract Background Polycystic ovary syndrome (PCOS) women have high incidences of dyslipidemia, obesity, impaired glucose tolerance (IGT), diabetes, and insulin resistance (IR) and are fragile to female infertility. Obesity and dyslipidemia may be the intermediate biological mechanism for the associations between glucose metabolism dysfunction and abnormal oogenesis and embryogenesis. Methods This retrospective cohort study was performed at a university-affiliated reproductive center. A total of 917 PCOS women aged between 20 and 45 undergoing their first IVF/ICSI embryo transfer cycles from January 2018 to December 2020 were involved. Associations between glucose metabolism indicators, adiposity and lipid metabolism indicators, and IVF/ICSI outcomes were explored using multivariable generalized linear models. Mediation analyses were further performed to examine the potential mediation role of adiposity and lipid metabolism indicators. Results Significant dose-dependent relationships were found between glucose metabolism indicators and IVF/ICSI early reproductive outcomes and between glucose metabolism indicators and adiposity and lipid metabolism indicators (all P < 0.05). Also, we found significant dose-dependent relationships between adiposity and lipid metabolism indicators and IVF/ICSI early reproductive outcomes (all P < 0.05). The mediation analysis indicated that elevated FPG, 2hPG, FPI, 2hPI, HbA1c, and HOMA2-IR were significantly associated with decreased retrieved oocyte count, MII oocyte count, normally fertilized zygote count, normally cleaved embryo count, high-quality embryo count, or blastocyst formation count after controlling for adiposity and lipid metabolism indicators. Serum TG mediated 6.0–31.0% of the associations; serum TC mediated 6.1–10.8% of the associations; serum HDL-C mediated 9.4–43.6% of the associations; serum LDL-C mediated 4.2–18.2% of the associations; and BMI mediated 26.7–97.7% of the associations. Conclusions Adiposity and lipid metabolism indicators (i.e., serum TG, serum TC, serum HDL-C, serum LDL-C, and BMI) are significant mediators of the effect of glucose metabolism indicators on IVF/ICSI early reproductive outcomes in PCOS women, indicating the importance of preconception glucose and lipid management and the dynamic equilibrium of glucose and lipid metabolism in PCOS women. |
| first_indexed | 2024-03-13T00:43:44Z |
| format | Article |
| id | doaj.art-953d3dcbf3cb4ede9766a37da57389bd |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-13T00:43:44Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
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| series | European Journal of Medical Research |
| spelling | doaj.art-953d3dcbf3cb4ede9766a37da57389bd2023-07-09T11:09:36ZengBMCEuropean Journal of Medical Research2047-783X2023-07-0128111210.1186/s40001-023-01174-8Adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in PCOS women undergoing IVF/ICSI cyclesHuahua Jiang0Manfei Si1Tian Tian2Huifeng Shi3Ning Huang4Hongbin Chi5Rui Yang6Xiaoyu Long7Jie Qiao8Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalNational Clinical Research Center for Obstetrics and Gynecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalAbstract Background Polycystic ovary syndrome (PCOS) women have high incidences of dyslipidemia, obesity, impaired glucose tolerance (IGT), diabetes, and insulin resistance (IR) and are fragile to female infertility. Obesity and dyslipidemia may be the intermediate biological mechanism for the associations between glucose metabolism dysfunction and abnormal oogenesis and embryogenesis. Methods This retrospective cohort study was performed at a university-affiliated reproductive center. A total of 917 PCOS women aged between 20 and 45 undergoing their first IVF/ICSI embryo transfer cycles from January 2018 to December 2020 were involved. Associations between glucose metabolism indicators, adiposity and lipid metabolism indicators, and IVF/ICSI outcomes were explored using multivariable generalized linear models. Mediation analyses were further performed to examine the potential mediation role of adiposity and lipid metabolism indicators. Results Significant dose-dependent relationships were found between glucose metabolism indicators and IVF/ICSI early reproductive outcomes and between glucose metabolism indicators and adiposity and lipid metabolism indicators (all P < 0.05). Also, we found significant dose-dependent relationships between adiposity and lipid metabolism indicators and IVF/ICSI early reproductive outcomes (all P < 0.05). The mediation analysis indicated that elevated FPG, 2hPG, FPI, 2hPI, HbA1c, and HOMA2-IR were significantly associated with decreased retrieved oocyte count, MII oocyte count, normally fertilized zygote count, normally cleaved embryo count, high-quality embryo count, or blastocyst formation count after controlling for adiposity and lipid metabolism indicators. Serum TG mediated 6.0–31.0% of the associations; serum TC mediated 6.1–10.8% of the associations; serum HDL-C mediated 9.4–43.6% of the associations; serum LDL-C mediated 4.2–18.2% of the associations; and BMI mediated 26.7–97.7% of the associations. Conclusions Adiposity and lipid metabolism indicators (i.e., serum TG, serum TC, serum HDL-C, serum LDL-C, and BMI) are significant mediators of the effect of glucose metabolism indicators on IVF/ICSI early reproductive outcomes in PCOS women, indicating the importance of preconception glucose and lipid management and the dynamic equilibrium of glucose and lipid metabolism in PCOS women.https://doi.org/10.1186/s40001-023-01174-8PCOSMediating effectAdiposity and lipid metabolismGlucose metabolism indicatorsIVF/ICSI outcomes |
| spellingShingle | Huahua Jiang Manfei Si Tian Tian Huifeng Shi Ning Huang Hongbin Chi Rui Yang Xiaoyu Long Jie Qiao Adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in PCOS women undergoing IVF/ICSI cycles European Journal of Medical Research PCOS Mediating effect Adiposity and lipid metabolism Glucose metabolism indicators IVF/ICSI outcomes |
| title | Adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in PCOS women undergoing IVF/ICSI cycles |
| title_full | Adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in PCOS women undergoing IVF/ICSI cycles |
| title_fullStr | Adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in PCOS women undergoing IVF/ICSI cycles |
| title_full_unstemmed | Adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in PCOS women undergoing IVF/ICSI cycles |
| title_short | Adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in PCOS women undergoing IVF/ICSI cycles |
| title_sort | adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in pcos women undergoing ivf icsi cycles |
| topic | PCOS Mediating effect Adiposity and lipid metabolism Glucose metabolism indicators IVF/ICSI outcomes |
| url | https://doi.org/10.1186/s40001-023-01174-8 |
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