Modifications to rhesus macaque TCR constant regions improve TCR cell surface expression.

T cell immunotherapy success is dependent on effective levels of antigen receptor expressed at the surface of engineered cells. Efforts to optimize surface expression in T cell receptor (TCR)-based therapeutic approaches include optimization of cellular engineering methods and coding sequences, and...

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Những tác giả chính: Lori V Coren, Matthew T Trivett, Jorden L Welker, James A Thomas, Robert J Gorelick, Emek Kose, Taina T Immonen, Kelli Czarra, Christine M Fennessey, Charles M Trubey, Jeffrey D Lifson, Adrienne E Swanstrom
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Public Library of Science (PLoS) 2025-01-01
Loạt:PLoS ONE
Truy cập trực tuyến:https://doi.org/10.1371/journal.pone.0314751