Modifications to rhesus macaque TCR constant regions improve TCR cell surface expression.
T cell immunotherapy success is dependent on effective levels of antigen receptor expressed at the surface of engineered cells. Efforts to optimize surface expression in T cell receptor (TCR)-based therapeutic approaches include optimization of cellular engineering methods and coding sequences, and...
Những tác giả chính: | , , , , , , , , , , , |
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Định dạng: | Bài viết |
Ngôn ngữ: | English |
Được phát hành: |
Public Library of Science (PLoS)
2025-01-01
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Loạt: | PLoS ONE |
Truy cập trực tuyến: | https://doi.org/10.1371/journal.pone.0314751 |