A non-invasive strategy for suppressing asthmatic airway inflammation and remodeling: Inhalation of nebulized hypoxic hUCMSC-derived extracellular vesicles

A non-invasive strategy for suppressing asthmatic airway inflammation and remodeling: Inhalation of nebulized hypoxic hUCMSC-derived extracellular vesicles

Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are extremely promising nanoscale cell-free therapeutic agents. We previously identified that intravenous administration (IV) of human umbilical cord MSC-EVs (hUCMSC-EVs), especially hypoxic hUCMSC-EVs (Hypo-EVs), could suppress aller...

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Bibliographic Details
Main Authors: Xiaowei Xu, Ying Wang, Xinkai Luo, Xuerong Gao, Weifeng Gu, Yongbin Ma, Lili Xu, Mengzhu Yu, Xi Liu, Jiameng Liu, Xuefeng Wang, Tingting Zheng, Chaoming Mao, Liyang Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
inhalation device
nebulized administration
mesenchymal stem cells
extracellular vesicles
asthma
lung injury
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1150971/full

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