Levels of lethal antibody during the course of infection with Schistosoma mansoni in rats and mice
Schistosoma mansoni infected hosts produce an IgG that mediates the complement-dependent killing of schistosomula in vitro. In this study, we followed the levels of serum lethal antibody during infection of rats and mice. Rats presented detectable lethal activity early in the course of infection wit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1987-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800053 |
| _version_ | 1797715799599742976 |
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| author | M. de Fátima M. Horta F. J. Ramalho-Pinto |
| author_facet | M. de Fátima M. Horta F. J. Ramalho-Pinto |
| author_sort | M. de Fátima M. Horta |
| collection | DOAJ |
| description | Schistosoma mansoni infected hosts produce an IgG that mediates the complement-dependent killing of schistosomula in vitro. In this study, we followed the levels of serum lethal antibody during infection of rats and mice. Rats presented detectable lethal activity early in the course of infection with a peak in the 6-8th week of infection. This activity declined to non-detectable levels within 2 weeks, remaining low up to the 20-26th week. In mice, lethal antibody was not detected before 7-12 weeks of infection, but raised to higher levels, as compared to non-infected animals, up to 20-24 weeks after infection. We correlate lethal antibody and protective immunity suggesting that the antibody-mediated complement-dependent cytotoxicity to schistosomula play a role in the immunity to reinfection. |
| first_indexed | 2024-03-12T08:12:06Z |
| format | Article |
| id | doaj.art-9541849b41064f2e8003a02f88cefeb7 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:12:06Z |
| publishDate | 1987-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-9541849b41064f2e8003a02f88cefeb72023-09-02T19:06:44ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601987-01-018228328410.1590/S0074-02761987000800053Levels of lethal antibody during the course of infection with Schistosoma mansoni in rats and miceM. de Fátima M. HortaF. J. Ramalho-PintoSchistosoma mansoni infected hosts produce an IgG that mediates the complement-dependent killing of schistosomula in vitro. In this study, we followed the levels of serum lethal antibody during infection of rats and mice. Rats presented detectable lethal activity early in the course of infection with a peak in the 6-8th week of infection. This activity declined to non-detectable levels within 2 weeks, remaining low up to the 20-26th week. In mice, lethal antibody was not detected before 7-12 weeks of infection, but raised to higher levels, as compared to non-infected animals, up to 20-24 weeks after infection. We correlate lethal antibody and protective immunity suggesting that the antibody-mediated complement-dependent cytotoxicity to schistosomula play a role in the immunity to reinfection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800053 |
| spellingShingle | M. de Fátima M. Horta F. J. Ramalho-Pinto Levels of lethal antibody during the course of infection with Schistosoma mansoni in rats and mice Memorias do Instituto Oswaldo Cruz |
| title | Levels of lethal antibody during the course of infection with Schistosoma mansoni in rats and mice |
| title_full | Levels of lethal antibody during the course of infection with Schistosoma mansoni in rats and mice |
| title_fullStr | Levels of lethal antibody during the course of infection with Schistosoma mansoni in rats and mice |
| title_full_unstemmed | Levels of lethal antibody during the course of infection with Schistosoma mansoni in rats and mice |
| title_short | Levels of lethal antibody during the course of infection with Schistosoma mansoni in rats and mice |
| title_sort | levels of lethal antibody during the course of infection with schistosoma mansoni in rats and mice |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800053 |
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