Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies
Septic arthritis, characterized as one of the most aggressive joint diseases, is primarily attributed to Staphylococcus aureus (S. aureus) and often results from hematogenous dissemination. Even with prompt treatment, septic arthritis frequently inflicts irreversible joint damage, leading to sustain...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1356982/full |
| _version_ | 1827353328414097408 |
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| author | Tao Jin Tao Jin |
| author_facet | Tao Jin Tao Jin |
| author_sort | Tao Jin |
| collection | DOAJ |
| description | Septic arthritis, characterized as one of the most aggressive joint diseases, is primarily attributed to Staphylococcus aureus (S. aureus) and often results from hematogenous dissemination. Even with prompt treatment, septic arthritis frequently inflicts irreversible joint damage, leading to sustained joint dysfunction in a significant proportion of patients. Despite the unsatisfactory outcomes, current therapeutic approaches for septic arthritis have remained stagnant for decades. In the clinical context, devising innovative strategies to mitigate joint damage necessitates a profound comprehension of the pivotal disease mechanisms. This entails unraveling how bacterial virulence factors interact with host elements to facilitate bacterial invasion into the joint and identifying the principal drivers of joint damage. Leveraging animal models of septic arthritis emerges as a potent tool to achieve these objectives. This review provides a comprehensive overview of the historical evolution and recent advancements in septic arthritis models. Additionally, we address practical considerations regarding experimental protocols. Furthermore, we delve into the utility of these animal models, such as their contribution to the discovery of novel bacterial virulence factors and host elements that play pivotal roles in the initiation and progression of septic arthritis. Finally, we summarize the latest developments in novel therapeutic strategies against septic arthritis, leveraging insights gained from these unique animal models. |
| first_indexed | 2024-03-08T03:23:40Z |
| format | Article |
| id | doaj.art-9543bf3cde104fd6874280e0fbabed55 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-08T03:23:40Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-9543bf3cde104fd6874280e0fbabed552024-02-12T04:46:29ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-02-011510.3389/fmicb.2024.13569821356982Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapiesTao Jin0Tao Jin1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Rheumatology, Sahlgrenska University Hospital, Gothenburg, SwedenSeptic arthritis, characterized as one of the most aggressive joint diseases, is primarily attributed to Staphylococcus aureus (S. aureus) and often results from hematogenous dissemination. Even with prompt treatment, septic arthritis frequently inflicts irreversible joint damage, leading to sustained joint dysfunction in a significant proportion of patients. Despite the unsatisfactory outcomes, current therapeutic approaches for septic arthritis have remained stagnant for decades. In the clinical context, devising innovative strategies to mitigate joint damage necessitates a profound comprehension of the pivotal disease mechanisms. This entails unraveling how bacterial virulence factors interact with host elements to facilitate bacterial invasion into the joint and identifying the principal drivers of joint damage. Leveraging animal models of septic arthritis emerges as a potent tool to achieve these objectives. This review provides a comprehensive overview of the historical evolution and recent advancements in septic arthritis models. Additionally, we address practical considerations regarding experimental protocols. Furthermore, we delve into the utility of these animal models, such as their contribution to the discovery of novel bacterial virulence factors and host elements that play pivotal roles in the initiation and progression of septic arthritis. Finally, we summarize the latest developments in novel therapeutic strategies against septic arthritis, leveraging insights gained from these unique animal models.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1356982/fullseptic arthritisanimal modelsbacterial virulencehost factorstherapeutic strategies |
| spellingShingle | Tao Jin Tao Jin Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies Frontiers in Microbiology septic arthritis animal models bacterial virulence host factors therapeutic strategies |
| title | Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies |
| title_full | Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies |
| title_fullStr | Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies |
| title_full_unstemmed | Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies |
| title_short | Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies |
| title_sort | exploring the role of bacterial virulence factors and host elements in septic arthritis insights from animal models for innovative therapies |
| topic | septic arthritis animal models bacterial virulence host factors therapeutic strategies |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1356982/full |
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