OX40 (CD134) Expression on T Regulatory Cells Is Related to Serious Hypertensive Disorders in Pregnancy
Hypertension is one of the leading causes of morbidity and mortality among women related to pregnancy, childbirth and the postpartum period. The pathogenesis of gestational hypertension is complex and still not fully understood. The aim of this study was to assess the population of circulating CD4+C...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/10/431 |
| _version_ | 1797573469901160448 |
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| author | Maciej Kwiatek Agnieszka Kojak Anna Kwaśniewska |
| author_facet | Maciej Kwiatek Agnieszka Kojak Anna Kwaśniewska |
| author_sort | Maciej Kwiatek |
| collection | DOAJ |
| description | Hypertension is one of the leading causes of morbidity and mortality among women related to pregnancy, childbirth and the postpartum period. The pathogenesis of gestational hypertension is complex and still not fully understood. The aim of this study was to assess the population of circulating CD4+CD25+FoxP3+ cells and its differentiation in terms of OX40 expression in two forms of hypertension: isolated hypertension developing after the 20th week of pregnancy and pre-eclampsia. The study included a group of 60 patients with hypertension and 48 healthy controls. The analysis of the percentage of Tregs was performed by flow cytometry. There was no difference in the percentage of peripheral lymphocytes between the groups. In the group of women with preeclampsia compared to the group with gestational hypertension, significantly higher percentages of CD4+CD25+FoxP3+ cells (<i>p</i> = 0.03) and percentages of CD4+CD25+FoxP3+ cells expressing the OX40 antigen (<i>p</i> = 0.001) were observed. OX40 expression on Tregs seems to be related to more serious type of hypertensive disorders in pregnant women. |
| first_indexed | 2024-03-10T21:10:58Z |
| format | Article |
| id | doaj.art-9547a02965dd448d9ea681156cd7bcde |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T21:10:58Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-9547a02965dd448d9ea681156cd7bcde2023-11-19T16:50:51ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-10-01101043110.3390/jcdd10100431OX40 (CD134) Expression on T Regulatory Cells Is Related to Serious Hypertensive Disorders in PregnancyMaciej Kwiatek0Agnieszka Kojak1Anna Kwaśniewska2Department of Obstetrics and Pregnancy Pathology, Medical University of Lublin, 20-059 Lublin, PolandDepartment of Obstetrics and Pregnancy Pathology, Medical University of Lublin, 20-059 Lublin, PolandDepartment of Obstetrics and Pregnancy Pathology, Medical University of Lublin, 20-059 Lublin, PolandHypertension is one of the leading causes of morbidity and mortality among women related to pregnancy, childbirth and the postpartum period. The pathogenesis of gestational hypertension is complex and still not fully understood. The aim of this study was to assess the population of circulating CD4+CD25+FoxP3+ cells and its differentiation in terms of OX40 expression in two forms of hypertension: isolated hypertension developing after the 20th week of pregnancy and pre-eclampsia. The study included a group of 60 patients with hypertension and 48 healthy controls. The analysis of the percentage of Tregs was performed by flow cytometry. There was no difference in the percentage of peripheral lymphocytes between the groups. In the group of women with preeclampsia compared to the group with gestational hypertension, significantly higher percentages of CD4+CD25+FoxP3+ cells (<i>p</i> = 0.03) and percentages of CD4+CD25+FoxP3+ cells expressing the OX40 antigen (<i>p</i> = 0.001) were observed. OX40 expression on Tregs seems to be related to more serious type of hypertensive disorders in pregnant women.https://www.mdpi.com/2308-3425/10/10/431gestational hypertensionpreeclampsiaT regulatory cellsOX40 |
| spellingShingle | Maciej Kwiatek Agnieszka Kojak Anna Kwaśniewska OX40 (CD134) Expression on T Regulatory Cells Is Related to Serious Hypertensive Disorders in Pregnancy Journal of Cardiovascular Development and Disease gestational hypertension preeclampsia T regulatory cells OX40 |
| title | OX40 (CD134) Expression on T Regulatory Cells Is Related to Serious Hypertensive Disorders in Pregnancy |
| title_full | OX40 (CD134) Expression on T Regulatory Cells Is Related to Serious Hypertensive Disorders in Pregnancy |
| title_fullStr | OX40 (CD134) Expression on T Regulatory Cells Is Related to Serious Hypertensive Disorders in Pregnancy |
| title_full_unstemmed | OX40 (CD134) Expression on T Regulatory Cells Is Related to Serious Hypertensive Disorders in Pregnancy |
| title_short | OX40 (CD134) Expression on T Regulatory Cells Is Related to Serious Hypertensive Disorders in Pregnancy |
| title_sort | ox40 cd134 expression on t regulatory cells is related to serious hypertensive disorders in pregnancy |
| topic | gestational hypertension preeclampsia T regulatory cells OX40 |
| url | https://www.mdpi.com/2308-3425/10/10/431 |
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